Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals
- Archibald, Stephen J.
- Tarn, Mark D.
- K?z?lyer, Nuray Yavuzkanat
- Joshi, Pankaj
- Brown, Nathaniel J.
- Pamme, Nicole
- Jenkins, David G.
- Esfahani, Mohammad M. N.
DOIAbstract
A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide [18F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards
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