Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet

This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.This is the peer-reviewed version of the following article: Chen, Qiushui, Utech, Stefanie, Chen, Dong, Prodanović, Radivoje, Lin, Jin-Ming, Weitz, David A., 2016. Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. Lab on A Chip. 16, 1346-1349. [https://doi.org/10.1039/c6lc00231e]Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3427