Add to ORKGIn this work, an innovative series of methylselenoesters as methylselenol precursors has been designed, synthesized and evaluated. The chemical characteristics of the carbonyl-selenium bond allow a nucleophilic attack that can render methylselenol, a key molecule in selenium biological activity. The scaffolds were chosen among carboaromatic and heteroaromatic rings with reported antitumoral activity to improve the action of methylselenol and to provide enough chemical variety to modulate the strength of the carbonyl-selenium bond, therefore hindering or facilitating a nucleophilic attack, i.e., by water. The release rate of methylselenol was determined, as well as the cytotoxic activity of the compounds against a panel of cancer cell lines....
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...
Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide du...
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...
In this work, an innovative series of methylselenoesters as methylselenol precursors has been design...
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effe...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potenti...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potenti...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potent...
The public perception of selenium has changed significantly over the last decades. Originally mainly...
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effe...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potent...
In this study, we report on the synthesis of new organoselenium derivatives, including nonsteroidal ...
A series of thirty-three novel selenium-containing compounds with potential antitumoral and/or leish...
A series of thirty-three novel selenium-containing compounds with potential antitumoral and/or leish...
Trace element selenium (Se) is fundamental to human health and, over the last years, research has fo...
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...
Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide du...
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...
In this work, an innovative series of methylselenoesters as methylselenol precursors has been design...
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effe...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potenti...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potenti...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potent...
The public perception of selenium has changed significantly over the last decades. Originally mainly...
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effe...
Redox active selenium (Se) compounds have gained substantial attention in the last decade as potent...
In this study, we report on the synthesis of new organoselenium derivatives, including nonsteroidal ...
A series of thirty-three novel selenium-containing compounds with potential antitumoral and/or leish...
A series of thirty-three novel selenium-containing compounds with potential antitumoral and/or leish...
Trace element selenium (Se) is fundamental to human health and, over the last years, research has fo...
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...
Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide du...
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...