Lurbinectedin is a novel highly selective inhibitor of RNA polymerase II triggering caspase-dependent apoptosis of cancerous cells. This article describes the development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay to quantify lurbinectedin in human plasma and urine. Plasma samples were pre-treated with 1 M aqueous ammonia after which they were brought onto supported liquid extraction (SLE) columns. Lurbinectedin was eluted from the columns using tert-butyl methyl ether (TBME). Urine was first diluted in plasma and lurbinectedin was extracted from this matrix by liquid-liquid extraction using TBME. Samples were measured by LC-MS/MS in the positive electron ion spray mode. The method was linear over 0....
Tasquinimod is an anti-tumor drug that is currently in clinical development for the treatment of sol...
Summary: Plitidepsin (Aplidin®) is a marine-derived anticancer compound currently investigated in ph...
Bioanalytical method development plays importance role in the pre-clinical and clinical studies. Pha...
Lurbinectedin is a novel highly selective inhibitor of RNA polymerase II triggering caspase-dependen...
Plitidepsin is an anti-cancer drug currently evaluated in phase I/II/III clinical trials. This artic...
Background: A liquid chromatography/tandem mass spectrometry assay was developed to facilitate thera...
A rapid high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was de-velo...
There is a vast increase in the number of newly developed anticancer therapeutics, of which marine-d...
A liquid chromatography-tandem mass spectrometry assay was developed and validated for the nine oral...
In this thesis, the development and validation of liquid chromatography tandem mass spectrometric (L...
PURPOSE: Plitidepsin absorption, distribution, metabolism and excretion characteristics were investi...
A simple, sensitive and specific liquid chromatography?tandem mass spectrometry (LC-MS/MS) method wa...
Liquid chromatography coupled to tandem mass spectrometry (LC-MS) has been used in the last two deca...
Tasquinimod is an anti-tumor drug that is currently in clinical development for the treatment of sol...
Summary: Plitidepsin (Aplidin®) is a marine-derived anticancer compound currently investigated in ph...
Bioanalytical method development plays importance role in the pre-clinical and clinical studies. Pha...
Lurbinectedin is a novel highly selective inhibitor of RNA polymerase II triggering caspase-dependen...
Plitidepsin is an anti-cancer drug currently evaluated in phase I/II/III clinical trials. This artic...
Background: A liquid chromatography/tandem mass spectrometry assay was developed to facilitate thera...
A rapid high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was de-velo...
There is a vast increase in the number of newly developed anticancer therapeutics, of which marine-d...
A liquid chromatography-tandem mass spectrometry assay was developed and validated for the nine oral...
In this thesis, the development and validation of liquid chromatography tandem mass spectrometric (L...
PURPOSE: Plitidepsin absorption, distribution, metabolism and excretion characteristics were investi...
A simple, sensitive and specific liquid chromatography?tandem mass spectrometry (LC-MS/MS) method wa...
Liquid chromatography coupled to tandem mass spectrometry (LC-MS) has been used in the last two deca...
Tasquinimod is an anti-tumor drug that is currently in clinical development for the treatment of sol...
Summary: Plitidepsin (Aplidin®) is a marine-derived anticancer compound currently investigated in ph...
Bioanalytical method development plays importance role in the pre-clinical and clinical studies. Pha...