Účinnost a bezpečnost léčby NOAC

Anticoagulation treatment has dramatically changed in recent years with the arrival of new molecules with different properties compared to a commonly used drugs. Massive expansion of these drugs is prevented by their high price and an indication of health insurance companies. In the first part of this thesis is described the process of blood clotting and its pathology, commonly used drugs such as heparin and warfarin, and new anticoagulants NOAC, their agents, properties, indications and contraindications