This bachelor thesis is focused on a proposal of air-conditioning for operating rooms and hinterlands of adjacent clean spaces, clean corridors, rooms for patient preparation and cleaning etc. Air-conditioning units are designed according to functional, operational and hygienic requirements of microclimates of buildings. The theoretical part is focused on structural composition of air-conditioning units for spaces with high purity requirements. The calculation and project documentation part consist of designing three air conditioning devices for air-conditioning of operating rooms and adjacent clean spaces. The result of the thesis is detailed design and project documentation of these three devices