As other many transcription factors, FoxO family members are involved in several cellular processes, including proliferation, apoptosis, stress resistance and metabolism. Their activity is finely regulated by phosphorylation, acetylation and ubiquitination events, which are modulated by multiple signalling pathways. Through the combination of specific post-translational modifications, composing a unique “molecular FoxO code”, FoxO proteins modulate different physiological processes and pathological events, such as cancer. Previously, a mitochondrial arm of the AMPK-FoxO3A axis, representing a mechanism sustaining the energy metabolism upon nutrient shortage, has been revealed in normal cells and tissues. Data collected during this projec...
Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting develop...
Abstract FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a v...
The development of acquired resistance to chemotherapeutic drugs is often a limiting factor in the t...
While aberrant cancer cell growth is frequently associated with altered biochemical metabolism, norm...
While aberrant cancer cell growth is frequently associated with altered biochemical metabolism, norm...
While aberrant cancer cell growth is frequently associated with altered biochemical metabolism, norm...
Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromol...
Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it invo...
Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it invo...
Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinosi...
Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it invo...
Cellular stress response is a universal mechanism that ensures the survival or negative selection of...
Cellular stress response is a universal mechanism that ensures the survival or negative selection of...
Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromol...
FOXO transcription factors are involved in a variety of biological processes including cell cycle re...
Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting develop...
Abstract FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a v...
The development of acquired resistance to chemotherapeutic drugs is often a limiting factor in the t...
While aberrant cancer cell growth is frequently associated with altered biochemical metabolism, norm...
While aberrant cancer cell growth is frequently associated with altered biochemical metabolism, norm...
While aberrant cancer cell growth is frequently associated with altered biochemical metabolism, norm...
Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromol...
Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it invo...
Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it invo...
Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinosi...
Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it invo...
Cellular stress response is a universal mechanism that ensures the survival or negative selection of...
Cellular stress response is a universal mechanism that ensures the survival or negative selection of...
Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromol...
FOXO transcription factors are involved in a variety of biological processes including cell cycle re...
Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting develop...
Abstract FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a v...
The development of acquired resistance to chemotherapeutic drugs is often a limiting factor in the t...