Cognitive-behavioral therapy for drug-resistant obsessivecompulsive disorder Terapia cognitvo-conductual en pacientes con trastorno obsesivo compulsivo resistentes a la farmacoterapia

Background: The purpose of the present study was to examine the efficacy of cognitive- behavioural therapy (CBT) in a consecutive sample of patients suffering from drug-resistant obsessive-compulsive disorder (OCD) and to explore variables related to outcome. Method: Coadjuvant CBT was prescribed to 23 adult outpatients diagnosed with drug-resistant OCD (at least 2 different drugs had been prescribed). CBT had a maximum duration of 1 year, and was conducted in weekly, fortnightly, or monthly sessions. Subjects were assessed at baseline (T0), six months (T1), and twelve months (T2) by means of semi-structured interviews, Y-BOCS, CGI-Severity and CGIGlobal Improvement. Results: Four patients (17,4%) dropped out. The remaining 19 patients attended an average of 22,1 sessions. Large and significant (p=0,001) improvement of symptomathology (Y-BOCS) was observed in 73,9% of those who completed the process and 60,7% in the total sample (intent to treat analysis). Most of the improvement occu