Add to ORKGIt is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism...
Purpose of reviewWe focus on the molecular and cellular basis of the improvement in myocardial energ...
Heart failure may promote metabolic changes such as insulin resistance, in part through neurohumoral...
Objectives. We will review current concepts regarding bioenergetic decline in heart failure (HF). In...
It is unknown why heart failure progresses even when patients are treated with the best therapy avai...
Despite advances in treatment, chronic heart failure is still associated with significant morbidity ...
Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the...
The failing heart has an increased metabolic demand and at the same time suffers from impaired energ...
The morbidity and mortality of coronary heart disease and of heart failure remain unacceptably high ...
The incidence and prevalence of heart failure have increased significantly over the past few decades...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
AbstractThe heart is responsible for pumping blood throughout the blood vessels to the periphery by ...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal c...
Energy substrate metabolism and contractile function are tightly coupled in the heart. Within this f...
AbstractHeart failure is a major cause of morbidity and mortality in the world. Cardiac energy metab...
Purpose of reviewWe focus on the molecular and cellular basis of the improvement in myocardial energ...
Heart failure may promote metabolic changes such as insulin resistance, in part through neurohumoral...
Objectives. We will review current concepts regarding bioenergetic decline in heart failure (HF). In...
It is unknown why heart failure progresses even when patients are treated with the best therapy avai...
Despite advances in treatment, chronic heart failure is still associated with significant morbidity ...
Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the...
The failing heart has an increased metabolic demand and at the same time suffers from impaired energ...
The morbidity and mortality of coronary heart disease and of heart failure remain unacceptably high ...
The incidence and prevalence of heart failure have increased significantly over the past few decades...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
AbstractThe heart is responsible for pumping blood throughout the blood vessels to the periphery by ...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal c...
Energy substrate metabolism and contractile function are tightly coupled in the heart. Within this f...
AbstractHeart failure is a major cause of morbidity and mortality in the world. Cardiac energy metab...
Purpose of reviewWe focus on the molecular and cellular basis of the improvement in myocardial energ...
Heart failure may promote metabolic changes such as insulin resistance, in part through neurohumoral...
Objectives. We will review current concepts regarding bioenergetic decline in heart failure (HF). In...