The development of morphine-tolerance after chronic administration, reduces analgesic efficacy and is a significant clinical problem in some patients; may be managed clinically by increasing the doses of morphine and/or the administration of a second mu-opioid agonist. In morphine-tolerant mice, we investigated the presence of an interaction when two opioids are administered simultaneously. We determined the antinociceptive effects of morphine (M), fentanyl (FEN), and tramadol (TRM) individually and combined in a 1:1 proportion, based on their potency. Nociceptive thresholds were evaluated in CD1 mice using the hot plate test. Morphine tolerance was induced by the subcutaneous implantation of a 75mg morphine pellet, whereas control animals ...
Mitragynine (MG) is the major active alkaloid found in Mitragyna speciosa Korth. In the present stud...
Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid ana...
<p>Top. Morphine induced dose-dependent antinociception in both mu-cKO and mu<sup>fl</sup> mice in t...
The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentan...
The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentan...
Artículo de publicación ISIBackground: Opioids have been used for the management of pain and coadmin...
Fentanyl has been shown to be a potent analgesic with a lower propensity to produce tolerance and ph...
Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic and inflam...
Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic antinociceptive syn...
Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic and inflam...
Systemic administration of morphine typically produces greater tolerance than higher efficacy mu-opi...
The antinociceptive activity of dexketoprofen was studied in mice using the formalin assay for orofa...
The irreversible cholinesterase inhibitor diisopropylphosphofluoridate (DFP) causes a naloxone-sensi...
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, parace...
Background – Benzodiazepines have been used with opiates to give better pain relief than opiates alo...
Mitragynine (MG) is the major active alkaloid found in Mitragyna speciosa Korth. In the present stud...
Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid ana...
<p>Top. Morphine induced dose-dependent antinociception in both mu-cKO and mu<sup>fl</sup> mice in t...
The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentan...
The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentan...
Artículo de publicación ISIBackground: Opioids have been used for the management of pain and coadmin...
Fentanyl has been shown to be a potent analgesic with a lower propensity to produce tolerance and ph...
Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic and inflam...
Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic antinociceptive syn...
Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic and inflam...
Systemic administration of morphine typically produces greater tolerance than higher efficacy mu-opi...
The antinociceptive activity of dexketoprofen was studied in mice using the formalin assay for orofa...
The irreversible cholinesterase inhibitor diisopropylphosphofluoridate (DFP) causes a naloxone-sensi...
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, parace...
Background – Benzodiazepines have been used with opiates to give better pain relief than opiates alo...
Mitragynine (MG) is the major active alkaloid found in Mitragyna speciosa Korth. In the present stud...
Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid ana...
<p>Top. Morphine induced dose-dependent antinociception in both mu-cKO and mu<sup>fl</sup> mice in t...