Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive pancreatic β cell destruction. The disease is triggered by a combination of genetic and environmental factors, but the mechanisms leading to the triggering of early innate and late adaptive immunity and consequent progressive pancreatic β cell death remain unclear. The insulin-producing β cells are active secretory cells and are thus particularly sensitive to endoplasmic reticulum (ER) stress. ER stress plays an important role in the pathologic pathway leading to autoimmunity, islet inflammation, and β cell death. We show here that group B coxsackievirus (CVB) infection, a putative causative factor for T1D, induces a partial ER stress in rat a...
Abstract: Components of the unfolded protein response (UPR) modulate beta cell inflammation and deat...
Protein synthesis is increased by several-fold in stimulated pancreatic beta cells. Synthesis and fo...
Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to ...
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive p...
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive p...
Type 1 diabetes (T1D) is an autoimmune disease caused by loss of pancreatic β cells via apoptosis wh...
Enteroviruses, particularly the group B coxsackieviruses (CVBs), have been associated with the devel...
Coxsackievirus infections are believed to be a relevant risk factor in the induction of pancreatic b...
There is considerable evidence supporting an association between enterovirus (EV), infection, partic...
Enteroviruses are important environmental contributors to islet inflammation (insulitis) in type 1 d...
Summary: The development of autoimmune disease type 1 diabetes (T1D) is determined by both genetic b...
Coxsackievirus infections have been proposed as an environmental trigger for the development of T-ce...
Type I diabetes is a multi-factorial disease resulting from the destruction of beta cells in the is...
Enteroviral infections are implicated in islet autoimmunity and type 1 diabetes (T1D) pathogenesis. ...
Aims/hypothesis: Proinflammatory cytokines contribute to beta cell damage in type 1 diabetes in part...
Abstract: Components of the unfolded protein response (UPR) modulate beta cell inflammation and deat...
Protein synthesis is increased by several-fold in stimulated pancreatic beta cells. Synthesis and fo...
Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to ...
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive p...
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive p...
Type 1 diabetes (T1D) is an autoimmune disease caused by loss of pancreatic β cells via apoptosis wh...
Enteroviruses, particularly the group B coxsackieviruses (CVBs), have been associated with the devel...
Coxsackievirus infections are believed to be a relevant risk factor in the induction of pancreatic b...
There is considerable evidence supporting an association between enterovirus (EV), infection, partic...
Enteroviruses are important environmental contributors to islet inflammation (insulitis) in type 1 d...
Summary: The development of autoimmune disease type 1 diabetes (T1D) is determined by both genetic b...
Coxsackievirus infections have been proposed as an environmental trigger for the development of T-ce...
Type I diabetes is a multi-factorial disease resulting from the destruction of beta cells in the is...
Enteroviral infections are implicated in islet autoimmunity and type 1 diabetes (T1D) pathogenesis. ...
Aims/hypothesis: Proinflammatory cytokines contribute to beta cell damage in type 1 diabetes in part...
Abstract: Components of the unfolded protein response (UPR) modulate beta cell inflammation and deat...
Protein synthesis is increased by several-fold in stimulated pancreatic beta cells. Synthesis and fo...
Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to ...