Add to ORKG© 2018 Dr. May Lin YapWith over 100 types of cancer known, the study presented in this thesis introduces novel means of targeting a wide range of cancers, rather than a specific cancer antigen. Here, unique cancer targets, such as components of the tumor microenvironment and monoclonal antibody opsonization are investigated as new approaches for cancer diagnosis and targeted therapy. The first part of the study investigates the possibility of targeting activated platelets in the tumor microenvironment as a novel cancer diagnostic target. I showed the feasibility of using a single-chain antibody, which targets the activated form of GPIIb/IIIa, the most abundant platelet-specific receptor on the platelet surface as a possible tool for cancer ...
Over the last decades many key pathways in cancer were identified, which raised interest in developm...
Although very promising, current cancer treatments applications, including immunotherapy, fail to tr...
Although very promising, current cancer treatments applications, including immunotherapy, fail to tr...
Rationale The early detection of primary tumours and metastatic disease is vital for successful ther...
Rationale The early detection of primary tumours and metastatic disease is vital for successful ther...
Rationale The early detection of primary tumours and metastatic disease is vital for successful ther...
Rationale: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypoth...
Rationale: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypoth...
Over the last two decades, a major focus in the biomedical research community has been placed on und...
During the past decade, the efficacy of new molecular targeted drugs such as monoclonal antibodies h...
With the landscape-transforming arrival of cancer immunotherapy, such as drugs that block immune che...
Platelets play a role in cancer progression by acting as a protective shield and dynamic reservoir o...
Platelets play a role in cancer progression by acting as a protective shield and dynamic reservoir o...
Over the last decades many key pathways in cancer were identified, which raised interest in developm...
Over the last decades many key pathways in cancer were identified, which raised interest in developm...
Over the last decades many key pathways in cancer were identified, which raised interest in developm...
Although very promising, current cancer treatments applications, including immunotherapy, fail to tr...
Although very promising, current cancer treatments applications, including immunotherapy, fail to tr...
Rationale The early detection of primary tumours and metastatic disease is vital for successful ther...
Rationale The early detection of primary tumours and metastatic disease is vital for successful ther...
Rationale The early detection of primary tumours and metastatic disease is vital for successful ther...
Rationale: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypoth...
Rationale: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypoth...
Over the last two decades, a major focus in the biomedical research community has been placed on und...
During the past decade, the efficacy of new molecular targeted drugs such as monoclonal antibodies h...
With the landscape-transforming arrival of cancer immunotherapy, such as drugs that block immune che...
Platelets play a role in cancer progression by acting as a protective shield and dynamic reservoir o...
Platelets play a role in cancer progression by acting as a protective shield and dynamic reservoir o...
Over the last decades many key pathways in cancer were identified, which raised interest in developm...
Over the last decades many key pathways in cancer were identified, which raised interest in developm...
Over the last decades many key pathways in cancer were identified, which raised interest in developm...
Although very promising, current cancer treatments applications, including immunotherapy, fail to tr...
Although very promising, current cancer treatments applications, including immunotherapy, fail to tr...