Systematic review of statistically-derived models of immunological response in HIV-infected adults on antiretroviral therapy in Sub-Saharan Africa

Sempa, Joseph B.
Ujeneza, Eva L.
Nieuwoudt, Martin

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Publication date

February 2017

DOI

10.1371/journal.pone.0171658.

Publisher

Public Library of Science (PLoS)

Abstract

CITATION: Sempa, J. B., Ujeneza, E. L. & Niewoudt, M. 2017. Systematic review of statistically-derived models of immunological response in HIV-infected adults on antiretroviral therapy in Sub-Saharan Africa. PLoS ONE, 12(2):e0171658, doi:10.1371/journal.pone.0171658.The original publication is available at http://journals.plos.org/plosoneIntroduction: In Sub-Saharan African (SSA) resource limited settings, Cluster of Differentiation 4 (CD4) counts continue to be used for clinical decision making in antiretroviral therapy (ART). Here, HIV-infected people often remain with CD4 counts <350 cells/μL even after 5 years of viral load suppression. Ongoing immunological monitoring is necessary. Due to varying statistical modeling methods comparing...