Add to ORKGMost multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical rules. For various reasons, such methods may fail to produce biologically meaningful alignments. Herein, we describe a semi-automatic approach to multiple sequence alignment where biological expert knowledge can be used to influence the alignment procedure. The user can specify parts of the sequences that are biologically related to each other; our software program uses these sites as anchor points and creates a multiple alignment respecting these user-defined constraints. By using known functionally, structurally or evolutionarily related positions of the input sequences as anchor points, our method can produce alignments that reflect the t...
Abstract—This paper introduces a simple and effective approach to improve the accuracy of multiple s...
This review focuses on recent trends in multiple sequence alignment tools. It describes the latest a...
The level of conservation between two homologous sequences often varies among sequence regions; func...
Most multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical...
Abstract: In many situations, automated multi-alignment programs are not able to correctly align fam...
Background: Automated software tools for multiple alignment often fail to produce biologically meani...
Alignment of multiple DNA or protein sequences is a cen-tral problem in computational biology. To cr...
Sequence alignment has become one of the most common tasks in bioinformatics. Most of the existing s...
Recent advances in evolutionary modelling and alignment methodology mean that today accurate and fas...
An essential tool in biology is the alignment of multiple sequences. Biologists use multiple sequenc...
Multiple sequence alignments are an indispensable tool in bioinformatics. Many applications rely on ...
An ever-increasing number of biological modelingmethods depend on the assembly of an accuratemultipl...
Abstract Multiple sequence alignment as a means of comparing DNA, RNA or amino acid sequences is an ...
This thesis summarizes ways of representation of biological sequences and file formats used for sequ...
To be able to understand characteristics and purpose of biological sequences correctly, it is crucia...
Abstract—This paper introduces a simple and effective approach to improve the accuracy of multiple s...
This review focuses on recent trends in multiple sequence alignment tools. It describes the latest a...
The level of conservation between two homologous sequences often varies among sequence regions; func...
Most multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical...
Abstract: In many situations, automated multi-alignment programs are not able to correctly align fam...
Background: Automated software tools for multiple alignment often fail to produce biologically meani...
Alignment of multiple DNA or protein sequences is a cen-tral problem in computational biology. To cr...
Sequence alignment has become one of the most common tasks in bioinformatics. Most of the existing s...
Recent advances in evolutionary modelling and alignment methodology mean that today accurate and fas...
An essential tool in biology is the alignment of multiple sequences. Biologists use multiple sequenc...
Multiple sequence alignments are an indispensable tool in bioinformatics. Many applications rely on ...
An ever-increasing number of biological modelingmethods depend on the assembly of an accuratemultipl...
Abstract Multiple sequence alignment as a means of comparing DNA, RNA or amino acid sequences is an ...
This thesis summarizes ways of representation of biological sequences and file formats used for sequ...
To be able to understand characteristics and purpose of biological sequences correctly, it is crucia...
Abstract—This paper introduces a simple and effective approach to improve the accuracy of multiple s...
This review focuses on recent trends in multiple sequence alignment tools. It describes the latest a...
The level of conservation between two homologous sequences often varies among sequence regions; func...