17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage
- Marini, Sandro
- Devan, William J.
- Radmanesh, Farid
- Miyares, Laura
- Poterba, Timothy
- Hansen, Björn M.
- Norrving, Bo
- Jimenez-Conde, Jordi
- Giralt-Steinhauer, Eva
- Elosua, Roberto
- Cuadrado-Godia, Elisa
- Soriano, Carolina
- Roquer, Jaume
- Kourkoulis, Christina E.
- Ayres, Alison M.
- Schwab, Kristin
- Tirschwell, David L.
- Selim, Magdy
- Brown, Devin L.
- Silliman, Scott L.
- Worrall, Bradford B.
- Meschia, James F.
- Kidwell, Chelsea S.
- Montaner, Joan
- Fernandez-Cadenas, Israel
- Delgado, Pilar
- Greenberg, Steven M.
- Lindgren, Arne
- Matouk, Charles
- Sheth, Kevin N.
- Woo, Daniel
- Anderson, Christopher D.
- Rosand, Jonathan
- Falcone, Guido J.
DOIAbstract
Background and Purpose-Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH. Methods-We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry. We utilized the admission head computed tomography to calculate hematoma volume via semiautomated computer-Assisted technique. After quality control and imputation, 7 million genetic variants were available for association testing with ICH volume, which was performed separately in lob...
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