BACKGROUND: Development of chemo-/radioresistance is a major challenge for the current prostate cancer (CaP) therapy. We have previously demonstrated that epithelial cell adhesion molecule (EpCAM) is associated with CaP growth and therapeutic resistance in vitro, however, the role of EpCAM in CaP in vivo is not fully elucidated. Here, we aimed to investigate how expression of EpCAM is involved in CaP growth and chemo-/radiotherapy response in NOD/SCID mouse models in vivo and to validate its role as a therapeutic target for CaP therapy. METHODS: EpCAM was knocked down in PC-3 CaP cell line using short hairpin RNA (shRNA). The effect of EpCAM-knockdown (KD) on tumour growth, chemo-/radiotherapy response and animal survival was evaluated on s...
<div><p>Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed...
Injection of tumor cells in mice more than 30 years ago resulted in the discovery of an epithelial a...
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in epithelial ti...
Abstract Background Development of chemo−/radioresistance is a major challenge for the current prost...
Despite significant advances in surgery, radiotherapy and chemotherapy to treat prostate cancer (CaP...
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colo...
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colo...
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecul...
Abstract Background The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed...
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on...
There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive mod...
Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed in epit...
There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive mod...
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on...
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane protein that is expressed in the...
<div><p>Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed...
Injection of tumor cells in mice more than 30 years ago resulted in the discovery of an epithelial a...
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in epithelial ti...
Abstract Background Development of chemo−/radioresistance is a major challenge for the current prost...
Despite significant advances in surgery, radiotherapy and chemotherapy to treat prostate cancer (CaP...
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colo...
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colo...
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecul...
Abstract Background The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed...
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on...
There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive mod...
Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed in epit...
There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive mod...
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on...
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane protein that is expressed in the...
<div><p>Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed...
Injection of tumor cells in mice more than 30 years ago resulted in the discovery of an epithelial a...
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in epithelial ti...