We used comparative genomics and experimental analyses to show that (1) eukaryotes and archaea, which possess the selenocysteine (Sec) protein insertion machinery contain an enzyme, O-phosphoseryl-transfer RNA (tRNA) [Ser]Sec kinase (designated PSTK), which phosphorylates seryl-tRNA [Ser]Sec to form O-phosphoseryl-tRNA [Ser]Sec and (2) the Sec synthase (SecS) in mammals is a pyridoxal phosphate-containing protein previously described as the soluble liver antigen (SLA). SecS uses the product of PSTK, Ophosphoseryl- tRNA [Ser]Sec, and selenophosphate as substrates to generate selenocysteyltRNA [Ser]Sec. Sec could be synthesized on tRNA [Ser]Sec from selenide, adenosine triphosphate (ATP), and serine using tRNA [Ser]Sec, seryl-tRNA synthetase...
Known eukaryotic selenocysteine (Sec)-containing proteins are animal proteins, whereas selenoprotein...
IThe amino acid selenocysteine is encoded by UGA, usually a stop codon, thus requiring a specialized...
Known eukaryotic selenocysteine (Sec)-containing proteins are animal proteins, whereas selenoprotein...
We used comparative genomics and experimental analyses to show that (1) eukaryotes and archaea, whic...
Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the...
Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the...
Selenocysteine (Sec), the 21st genetically encoded amino acid, is the major metabolite of the micron...
Selenocysteine (Sec) is the 21st genetically encoded amino acid found in organisms from all three do...
The complete sequencing of genomes and the development of in silico methods for identification of ge...
The complete sequencing of genomes and the development of in silico methods for identification of ge...
In 1970, a kinase activity that phosphorylated a minor species of seryl-tRNA to form phosphoseryl-tR...
In 1970, a kinase activity that phosphorylated a minor species of seryl-tRNA to form phosphoseryl-tR...
Selenocysteine (Sec) tRNA occupies a prominent position in the expression of selenoproteins as it is...
In eukaryotes and Archaea, selenocysteine synthase (SecS) converts O-phospho-L-seryl-tRNA[Ser]Sec in...
The trace element selenium is found in proteins as selenocysteine (Sec), the 21st amino acid to part...
Known eukaryotic selenocysteine (Sec)-containing proteins are animal proteins, whereas selenoprotein...
IThe amino acid selenocysteine is encoded by UGA, usually a stop codon, thus requiring a specialized...
Known eukaryotic selenocysteine (Sec)-containing proteins are animal proteins, whereas selenoprotein...
We used comparative genomics and experimental analyses to show that (1) eukaryotes and archaea, whic...
Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the...
Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the...
Selenocysteine (Sec), the 21st genetically encoded amino acid, is the major metabolite of the micron...
Selenocysteine (Sec) is the 21st genetically encoded amino acid found in organisms from all three do...
The complete sequencing of genomes and the development of in silico methods for identification of ge...
The complete sequencing of genomes and the development of in silico methods for identification of ge...
In 1970, a kinase activity that phosphorylated a minor species of seryl-tRNA to form phosphoseryl-tR...
In 1970, a kinase activity that phosphorylated a minor species of seryl-tRNA to form phosphoseryl-tR...
Selenocysteine (Sec) tRNA occupies a prominent position in the expression of selenoproteins as it is...
In eukaryotes and Archaea, selenocysteine synthase (SecS) converts O-phospho-L-seryl-tRNA[Ser]Sec in...
The trace element selenium is found in proteins as selenocysteine (Sec), the 21st amino acid to part...
Known eukaryotic selenocysteine (Sec)-containing proteins are animal proteins, whereas selenoprotein...
IThe amino acid selenocysteine is encoded by UGA, usually a stop codon, thus requiring a specialized...
Known eukaryotic selenocysteine (Sec)-containing proteins are animal proteins, whereas selenoprotein...