Add to ORKGWe report that proteins with the same function bind the same set of small molecules from a standardized chemical library. This observation led to a quantifiable and rapidly adaptable method for protein functional analysis using experimentally-derived ligand binding profiles. Ligand binding is measured using a high-throughput NMR ligand affinity screen with a structurally diverse chemical library. The method was demonstrated using a set of 19 proteins with a range of functions. A statistically significant similarity in ligand binding profiles was only observed between the two functionally identical albumins and between the five functionally similar amylases. This new approach is independent of sequence, structure or evolutionary information,...
SummaryComprehensive knowledge of protein-ligand interactions should provide a useful basis for anno...
With nearly 1,350 complete genome sequences available our understanding of biology at the molecular ...
Rapid and accurate functional assignment of novel proteins is increasing in importance, given the co...
We report that proteins with the same function bind the same set of small molecules from a standardi...
An abundance of protein structures emerging from structural genomics and the Protein Structure Initi...
With the completion of the Human Genome Project in 2001 and the subsequent explosion of organisms wi...
The Human Genome Project and similar efforts have resulted in the identification of an abundance of ...
SummaryProteins perform functions through interacting with other molecules. However, structural deta...
Many of today’s drug discovery programs utilize high-throughput screening methods that rely on quick...
With the completion of the Human Genome Project in 2001 and the subsequent explosion of organisms wi...
The expansion of protein-ligand annotation databases has enabled large-scale networking of proteins ...
AbstractBackground: There are many ways to represent a molecule's properties, including atomic-conne...
To exploit the vast amount of sequence information provided by the Genomic revolution, the biologica...
Functional annotation is seldom straightforward with complexities arising due to functional divergen...
The continued success of genome sequencing projects has resulted in a wealth of information, but 40-...
SummaryComprehensive knowledge of protein-ligand interactions should provide a useful basis for anno...
With nearly 1,350 complete genome sequences available our understanding of biology at the molecular ...
Rapid and accurate functional assignment of novel proteins is increasing in importance, given the co...
We report that proteins with the same function bind the same set of small molecules from a standardi...
An abundance of protein structures emerging from structural genomics and the Protein Structure Initi...
With the completion of the Human Genome Project in 2001 and the subsequent explosion of organisms wi...
The Human Genome Project and similar efforts have resulted in the identification of an abundance of ...
SummaryProteins perform functions through interacting with other molecules. However, structural deta...
Many of today’s drug discovery programs utilize high-throughput screening methods that rely on quick...
With the completion of the Human Genome Project in 2001 and the subsequent explosion of organisms wi...
The expansion of protein-ligand annotation databases has enabled large-scale networking of proteins ...
AbstractBackground: There are many ways to represent a molecule's properties, including atomic-conne...
To exploit the vast amount of sequence information provided by the Genomic revolution, the biologica...
Functional annotation is seldom straightforward with complexities arising due to functional divergen...
The continued success of genome sequencing projects has resulted in a wealth of information, but 40-...
SummaryComprehensive knowledge of protein-ligand interactions should provide a useful basis for anno...
With nearly 1,350 complete genome sequences available our understanding of biology at the molecular ...
Rapid and accurate functional assignment of novel proteins is increasing in importance, given the co...