Most of the tens of millions of clinical attacks caused by Plasmodium vivax each year likely originate from dormant liver forms called hypnozoites. We do not systematically attack that reservoir because the only drug available, primaquine, is poorly suited to doing so. Primaquine was licenced for anti-relapse therapy in 1952 and became available despite threatening patients having an inborn deficiency of glucose-6-phosphate dehydrogenase (G6PD) with acute haemolytic anaemia. The standard method for screening G6PD deficiency, the fluorescent spot test, has proved impractical where most malaria patients live. The blind administration of daily primaquine is dangerous, but so too are the relapses invited by withholding treatment. Absent G6PD sc...
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its...
The incidence and range of endemic malaria caused by Plasmodium vivax has expanded during the past 3...
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its...
Most of the tens of millions of clinical attacks caused by Plasmodium vivax each year likely origina...
Plasmodium vivax infects 130–435 million of the 2.6 billion people living at risk of infection. Rece...
Abstract The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and oppo...
The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity f...
Recent successes in malaria control have put malaria eradication back on the public health agenda. A...
Abstract Background Primaquine is currently the only medication used for radical cure of Plasmodium ...
BackgroundPrimaquine is essential for the radical cure of vivax malaria, however its broad applicati...
Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient indiv...
BACKGROUND: Primaquine is currently the only medication used for radical cure of Plasmodium vivax in...
Background: Primaquine is the only drug available for preventing relapse following a primary attack ...
Recent successes in malaria control have put malaria eradication back on the public health agenda. A...
Treatment of acutely ill patients, informed by a diagnosis of the species of Plasmodium involved, ha...
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its...
The incidence and range of endemic malaria caused by Plasmodium vivax has expanded during the past 3...
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its...
Most of the tens of millions of clinical attacks caused by Plasmodium vivax each year likely origina...
Plasmodium vivax infects 130–435 million of the 2.6 billion people living at risk of infection. Rece...
Abstract The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and oppo...
The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity f...
Recent successes in malaria control have put malaria eradication back on the public health agenda. A...
Abstract Background Primaquine is currently the only medication used for radical cure of Plasmodium ...
BackgroundPrimaquine is essential for the radical cure of vivax malaria, however its broad applicati...
Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient indiv...
BACKGROUND: Primaquine is currently the only medication used for radical cure of Plasmodium vivax in...
Background: Primaquine is the only drug available for preventing relapse following a primary attack ...
Recent successes in malaria control have put malaria eradication back on the public health agenda. A...
Treatment of acutely ill patients, informed by a diagnosis of the species of Plasmodium involved, ha...
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its...
The incidence and range of endemic malaria caused by Plasmodium vivax has expanded during the past 3...
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its...