The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in definitive erythrocytes: HbA (the major adult Hb isoform, with α-chain subunits encoded by the αA-globin gene) and HbD (the minor adult Hb isoform, with α-chain subunits encoded by the αD-globin gene). The αD-globin gene originated via tandem duplication of an embryonic α-like globin gene in the stem lineage of tetrapod vertebrates, which suggests the possibility that functional differentiation between the HbA and HbD isoforms may be attributable to a retained ancestral character state in HbD that harkens back to a primordial, embryonic function. To investigate this possibility and to examine other aspects of the evolution of the avian α-like globi...
This Article is brought to you for free and open access by the Biological Sciences, School of at Dig...
The α- and β-globin gene families of jawed vertebrates have diversified with respect to both gene fu...
Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced r...
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced r...
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced r...
Gene duplication is thought to play an important role in the co-option of existing protein functions...
Gene duplication is thought to play an important role in the co-option of existing protein functions...
In air-breathing vertebrates, the physiologically optimal blood-O2 affinity is jointly determined by...
Phylogenetic reconstructions of the β-globin gene family in vertebrates have revealed that developme...
In air-breathing vertebrates, the physiologically optimal blood-O2 affinity is jointly determined by...
This Article is brought to you for free and open access by the Biological Sciences, School of at Dig...
The α- and β-globin gene families of jawed vertebrates have diversified with respect to both gene fu...
Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in defini...
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced r...
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced r...
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced r...
Gene duplication is thought to play an important role in the co-option of existing protein functions...
Gene duplication is thought to play an important role in the co-option of existing protein functions...
In air-breathing vertebrates, the physiologically optimal blood-O2 affinity is jointly determined by...
Phylogenetic reconstructions of the β-globin gene family in vertebrates have revealed that developme...
In air-breathing vertebrates, the physiologically optimal blood-O2 affinity is jointly determined by...
This Article is brought to you for free and open access by the Biological Sciences, School of at Dig...
The α- and β-globin gene families of jawed vertebrates have diversified with respect to both gene fu...
Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms...