Add to ORKGBALB/c and severe combined immunodeficiency (SCID) mice were inoculated intracerebrally or intraperitoneally with scrapie agent strain ME7 to examine the role of functional lymphocytes and follicular dendritic cells in splenic infectivity and PrPsc accumulation. Intracerebrally inoculated BALB/c and SCID mice developed the clinical signs and microscopic lesions characteristic of scrapie. Spleens from terminally affected BALB/c mice contained PrPsc which was detectable by immunoblot analysis; SCID mouse spleens did not contain detectable PrP so. SCID mouse spleens collected during the first 90 days after intraperitoneal infection contained neither infectivity nor PrPsc
<p>PrP<sup>Sc</sup> in spleens from (B10 X A.BY)F1 mice inoculated i.v. with FV alone (A), i.p. with...
a<p>Mice inoculated with a 1∶10 dilution of a 22L mouse scrapie 10% brain homogenate. These mice wer...
Transmissible spongiform encephalopathies (TSEs) are a group of sub-acute infectious neurodegenerat...
Using the severe combined immunodeficiency (SCID) mouse model, we investigated the requirement of th...
The transmissible spongiform encephalopathies (TSEs) are a group of progressive neurological diseas...
Studies carried out during the 1970s-1980s, demonstrated that neonatal mice are less susceptible th...
Transmissible spongiform encephalopathies (TSEs), such as scrapie and variant Creutzfeldt-Jakob dis...
<p>Mice were challenged by oral (lane 5–8) or the intra-cerebral route (lanes 1–4). A) Western blot ...
Mice devoid of PrPC (Prnp%) are resistant to scrapie and do not allow propagation of the infectious ...
<p>Groups of four 129/Sv×C57BL/6 and <i>Prnp</i><sup>0/0</sup> mice were inoculated i.p. with 100 µl...
Background: The exact role of the lymphoreticular system in the spread of peripheral prion infect...
Although it is well established that the infectious agent can replicate in the lymphoreticular syste...
Additional file 1. PrPres accumulation in the spleen of TgOvPrP59 mice infected with a classical scr...
AbstractRecently, we reported that PrPSc, a surrogate marker for prion disease, is associated with t...
<p>Blots were developed using D13 anti-PrP <a href="http://www.plospathogens.org/article/info:doi/10...
<p>PrP<sup>Sc</sup> in spleens from (B10 X A.BY)F1 mice inoculated i.v. with FV alone (A), i.p. with...
a<p>Mice inoculated with a 1∶10 dilution of a 22L mouse scrapie 10% brain homogenate. These mice wer...
Transmissible spongiform encephalopathies (TSEs) are a group of sub-acute infectious neurodegenerat...
Using the severe combined immunodeficiency (SCID) mouse model, we investigated the requirement of th...
The transmissible spongiform encephalopathies (TSEs) are a group of progressive neurological diseas...
Studies carried out during the 1970s-1980s, demonstrated that neonatal mice are less susceptible th...
Transmissible spongiform encephalopathies (TSEs), such as scrapie and variant Creutzfeldt-Jakob dis...
<p>Mice were challenged by oral (lane 5–8) or the intra-cerebral route (lanes 1–4). A) Western blot ...
Mice devoid of PrPC (Prnp%) are resistant to scrapie and do not allow propagation of the infectious ...
<p>Groups of four 129/Sv×C57BL/6 and <i>Prnp</i><sup>0/0</sup> mice were inoculated i.p. with 100 µl...
Background: The exact role of the lymphoreticular system in the spread of peripheral prion infect...
Although it is well established that the infectious agent can replicate in the lymphoreticular syste...
Additional file 1. PrPres accumulation in the spleen of TgOvPrP59 mice infected with a classical scr...
AbstractRecently, we reported that PrPSc, a surrogate marker for prion disease, is associated with t...
<p>Blots were developed using D13 anti-PrP <a href="http://www.plospathogens.org/article/info:doi/10...
<p>PrP<sup>Sc</sup> in spleens from (B10 X A.BY)F1 mice inoculated i.v. with FV alone (A), i.p. with...
a<p>Mice inoculated with a 1∶10 dilution of a 22L mouse scrapie 10% brain homogenate. These mice wer...
Transmissible spongiform encephalopathies (TSEs) are a group of sub-acute infectious neurodegenerat...