Arthritis Care Res (Hoboken)

Objective.To explore associations of joint hypermobility (a condition where range of motion is greater than normal) with ankle and foot radiographic osteoarthritis and symptoms in a large community-based cohort of African American and Caucasian adults 55\u201394 years old.Methods.Ankle and foot radiographs and joint hypermobility data (Beighton Criteria) were available for 848 participants (2003\u20132010) in this cross-sectional study. General joint hypermobility was defined as a Beighton score 654 (range 0\u20139); knee hypermobility was defined as hyperextension of at least one knee. Standing anteroposterior and lateral foot radiographs were read with standard atlases for Kellgren-Lawrence grade, osteophytes and joint space narrowing at the tibiotalar joint and for osteophytes and joint space narrowing to define osteoarthritis at five foot joints. Ankle or foot symptoms were self-reported. Separate person-based logistic regression models were used to estimate associations of ankle and foot osteoarthritis and symptom outcomes with hypermobility measures, adjusting for age, sex, race, body mass index, and history of ankle/foot injury.Results.This sample was: 68% women and 33% African American; mean age=71 years; mean body mass index=31 kg/m2; general joint hypermobility=7%, knee hypermobility=4%; ankle injury=11.5%, foot injury=3.8%. Although general joint hypermobility was not associated with ankle and foot outcomes, knee hypermobility was associated with ankle symptoms, foot symptoms, and talonavicular osteoarthritis (adjusted odds ratios of 4.4, 2.4, and 3.0, respectively).Conclusions.Knee joint hypermobility may be related to talonavicular osteoarthritis and to ankle and foot symptoms.R01 AR067743/AR/NIAMS NIH HHS/United StatesU01 DP006266/DP/NCCDPHP CDC HHS/United StatesK23 AR061406/AR/NIAMS NIH HHS/United StatesS3486/CDC/Association of Schools of Public Health/InternationalU01 DP003206/DP/NCCDPHP CDC HHS/United StatesU01DP003206/ACL/ACL HHS/United StatesS043/CDC/Association of Schools of Public Health/InternationalP30 AG028716/AG/NIA NIH HHS/United StatesR01 AR047853/AR/NIAMS NIH HHS/United StatesP60 AR064166/AR/NIAMS NIH HHS/United States2020-04-01T00:00:00Z29953742PMC63106678874vault:3129