The somatic genomic landscape of glioblastoma
- C.W. Brennan
- R.G.W. Verhaak
- A. Mckenna
- B. Campos
- H. Noushmehr
- S.R. Salama
- S. Zheng
- D. Chakravarty
- J.Z. Sanborn
- S.H. Berman
- R. Beroukhim
- B. Bernard
- W. Chang-Jiun
- G. Genovese
- I. Shmulevich
- J. Barnholtz-Sloan
- L. Zou
- R. Vegesna
- S.A. Shukla
- G. Ciriello
- W.K. Yung
- W. Zhang
- C. Sougnez
- T. Mikkelsen
- K. Aldape
- D.D. Bigner
- E.G. Van Meir
- M. Prados
- A. Sloan
- K.L. Black
- J. Eschbacher
- G. Finocchiaro
- W. Friedman
- D.W. Andrews
- A. Guha
- M. Iacocca
- B.P. O&apos
- G. Foltz
- J. Myers
- D.J. Weisenberger
- R. Penny
- R. Kucherlapati
- C.M. Perou
- D.N. Hayes
- R. Gibbs
- M. Marra
- G.B. Mills
- E.S. Lander
- P. Spellman
- R. Wilson
- C. Sander
- J. Weinstein
- M. Meyerson
- S. Gabriel
- P.W. Laird
- D. Haussler
- G. Getz
- L. Chin
- C. Benz
- W. Barrett
- Q. Ostrom
- Y. Wolinsky
- B. Bose
- P.T. Boulos
- M. Boulos
- J. Brown
- C. Czerinski
- M. Eppley
- T. Kempista
- T. Kitko
- Y. Koyfman
- B. Rabeno
- P. Rastogi
- M. Sugarman
- P. Swanson
- K. Yalamanchii
- I.P. Otey
- Y.S. Liu
- Y. Xiao
- J.T. Auman
- P. Chen
- A. Hadjipanayis
- E. Lee
- S. Lee
- P.J. Park
- J. Seidman
- L. Yang
- S. Kalkanis
- L.M. Poisson
- A. Raghunathan
- L. Scarpace
- R. Bressler
- A. Eakin
- L. Iype
- R.B. Kreisberg
- K. Leinonen
- S. Reynolds
- H. Rovira
- V. Thorsson
- M.J. Annala
- J. Paulauskis
- E. Curley
- M. Hatfield
- D. Mallery
- S. Morris
- T. Shelton
- C. Shelton
- M. Sherman
- P. Yena
- L. Cuppini
- F. Dimeco
- M. Eoli
- E. Maderna
- B. Pollo
- M. Saini
- S. Balu
- K.A. Hoadley
- L. Ling
- C.R. Miller
- Y. Shi
- M.D. Topal
- W. Junyuan
- G. Dunn
- C. Giannini
- B.A. Aksoy
- Y. Antipin
- L. Borsu
- E. Cerami
- J. Gao
- B. Gross
- A. Jacobsen
- M. Ladanyi
- A. Lash
- Y. Liang
- B. Reva
- N. Schultz
- R. Shen
- N.D. Socci
- A. Viale
- M.L. Ferguson
- Q. Chen
- J.A. Demchok
- L.A.L. Dillon
- K.R. Mills Shaw
- M. Sheth
- R. Tarnuzzer
- Z. Wang
- L. Yang
- T. Davidsen
- M.S. Guyer
- B.A. Ozenberger
- H.J. Sofia
- J. Bergsten
- J. Eckman
- J. Harr
- C. Smith
- K. Tucker
- C. Winemiller
- L.A. Zach
- J.Y. Ljubimova
- G. Eley
- B. Ayala
- M.A. Jensen
- A. Kahn
- T.D. Pihl
- D.A. Pot
- Y. Wan
- N. Hansen
- P. Hothi
- B. Lin
- N. Shah
- J. Yoon
- C. Lau
- M. Berens
- K. Ardlie
- S.L. Carter
- A.D. Cherniack
- M. Noble
- J. Cho
- K. Cibulskis
- D. Dicara
- S. Frazer
- S.B. Gabriel
- N. Gehlenborg
- J. Gentry
- D. Heiman
- J. Kim
- R. Jing
- M. Lawrence
- P. Lin
- W. Mallard
- R.C. Onofrio
- G. Saksena
- S. Schumacher
- P. Stojanov
- B. Tabak
- D. Voet
- H. Zhang
- N.N. Dees
- L. Ding
- L.L. Fulton
- R.S. Fulton
- K. Kanchi
- E.R. Mardis
- R.K. Wilson
- S.B. Baylin
- L. Harshyne
- M.L. Cohen
- K. Devine
- A.E. Sloan
- S.R. Van Den Berg
- M.S. Berger
- D. Carlin
- B. Craft
- K. Ellrott
- M. Goldman
- T. Goldstein
- M. Grifford
- M. Singer
- N. Sam
- J. Stuart
- T. Swatloski
- P. Waltman
- J. Zhu
- R. Foss
- B. Frentzen
- R. Mctiernan
- A. Yachnis
- Y. Mao
- R. Akbani
- O. Bogler
- G.N. Fuller
- W. Liu
- Y. Liu
- L. Yiling
- A. Protopopov
- X. Ren
- Y. Sun
- W.K.A. Yung
- J. Zhang
- K. Chen
- J.N. Weinstein
- M.S. Bootwalla
- P.H. Lai
- T.J. Triche
- D.J. Van Den Berg
- D.H. Gutmann
- N.L. Lehman
- D. Brat
- J.J. Olson
- G.M. Mastrogianakis
- N.S. Devi
- Z. Zhang
- E. Lipp
- R. Mclendon
DOIAbstract
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations areshown tocorrelate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pat...
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