Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)

M. Cesari
B.W.J.H. Penninx
A.B. Newman
S.B. Kritchevsky
B.J. Nicklas
K. Sutton-Tyrrell
R.P. Tracy
S.M. Rubin
T.B. Harris
M. Pahor

Open link

Publication date

September 2003

DOI

10.1016/S0002-9149(03)00718-5

Publisher

Elsevier BV

ISSN

0002-9149

Citation count (estimate)

250

Abstract

This study investigates the association of several inflammatory markers with subclinical and clinical cardiovascular disease in older men and women. Data are from the baseline assessment of 3,045 well-functioning persons aged 70 to 79 years, participating in the Health, Aging and Body Composition study. The study sample was divided into 3 groups: "cardiovascular disease" (diagnosis of congestive heart failure, coronary artery disease, peripheral artery disease, or stroke), "subclinical cardiovascular disease" (positive findings on the Rose questionnaire for angina or claudication, ankle-brachial index <0.9, or electrocardiographic abnormalities), and "no cardiovascular disease." Serum levels of interleukin (IL)-6, C-reactive protein (CRP), ...