Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
- M.F. George
- F.B.S. Briggs
- X. Shao
- M.A. Gianfrancesco
- I. Kockum
- H.F. Harbo
- E.G. Celius
- S.D. Bos
- A. Hedströ
- L. Shen
- A. Bernstein
- L. Alfredsson
- J. Hillert
- T. Olsson
- N.A. Patsopoulos
- P.L. De Jager
- A.B. Oturai
- H.B. Sø
- F. Sellebjerg
- P.S. Sorensen
- R. Gomez
- S.J. Caillier
- B.A.C. Cree
- J.R. Oksenberg
- S.L. Hauser
- S. D&apos
- M.A. Leone
- F. Martinelli Boneschi
- M. Sorosina
- I. van der Mei
- B.V. Taylor
- Y. Zhou
- C. Schaefer
- L.F. Barcellos
DOIAbstract
OBJECTIVE: We investigated the association between 52 risk variants identified through genome-wide association studies and disease severity in multiple sclerosis (MS). METHODS: Ten unique MS case data sets were analyzed. The Multiple Sclerosis Severity Score (MSSS) was calculated using the Expanded Disability Status Scale at study entry and disease duration. MSSS was considered as a continuous variable and as 2 dichotomous variables (median and extreme ends; MSSS of 645 vs >5 and MSSS of <2.5 vs 657.5, respectively). Single nucleotide polymorphisms (SNPs) were examined individually and as both combined weighted genetic risk score (wGRS) and unweighted genetic risk score (GRS) for association with disease severity. Random-effects meta-an...
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