Phenotype definition is controlled by epigenetic regulations that allow cells to acquire their differentiated state. The process is reversible and attractive for therapeutic intervention and for the reactivation of hypermethylated pluripotency genes that facilitate transition to a higher plasticity state. We report the results obtained in human fibroblasts exposed to the epigenetic modifier 5-azacytidine (5-aza-CR), which increases adult cell plasticity and facilitates phenotype change. Although many aspects controlling its demethylating action have been widely investigated, the mechanisms underlying 5-aza-CR effects on cell plasticity are still poorly understood. Our experiments confirm decreased global methylation, but also demonstrate an...
Somatic embryogenesis (SE) is a widely studied process due to its biotechnological potential to gene...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
Covalent modification of DNA distinguishes cellular identities and is crucial for regulating the plu...
Phenotype definition is controlled by epigenetic regulations that allow cells to acquire their diffe...
Phenotype expression is controlled by epigenetic regulations that guide cells through differentiatio...
Phenotype definition is controlled by epigenetic regulations that allow cells to acquire their diffe...
Background: Global deregulation of DNA methylation is one of the crucial causes of hepato cellular c...
Development and cell differentiation are driven by complex epigenetic mechanisms that regulate chrom...
Recent experiments demonstrate that terminally differentiated cells can be induced to de-differentia...
In the last years, many works demonstrated the possibility to directly interact with the epigenetic ...
BACKGROUND: Cytosine methylation is a frequent epigenetic modification restricting the activity of g...
Background Global deregulation of DNA methylation is one of the crucial causes of hepato cellular ca...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
Background: Fragile X syndrome (FXS) is caused by CGG expansion over 200 repeats at the 5′ UTR of th...
We previously demonstrated that porcine fibroblasts exposed to 5-aza-cytidine (5-aza-CR), an inhibit...
Somatic embryogenesis (SE) is a widely studied process due to its biotechnological potential to gene...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
Covalent modification of DNA distinguishes cellular identities and is crucial for regulating the plu...
Phenotype definition is controlled by epigenetic regulations that allow cells to acquire their diffe...
Phenotype expression is controlled by epigenetic regulations that guide cells through differentiatio...
Phenotype definition is controlled by epigenetic regulations that allow cells to acquire their diffe...
Background: Global deregulation of DNA methylation is one of the crucial causes of hepato cellular c...
Development and cell differentiation are driven by complex epigenetic mechanisms that regulate chrom...
Recent experiments demonstrate that terminally differentiated cells can be induced to de-differentia...
In the last years, many works demonstrated the possibility to directly interact with the epigenetic ...
BACKGROUND: Cytosine methylation is a frequent epigenetic modification restricting the activity of g...
Background Global deregulation of DNA methylation is one of the crucial causes of hepato cellular ca...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
Background: Fragile X syndrome (FXS) is caused by CGG expansion over 200 repeats at the 5′ UTR of th...
We previously demonstrated that porcine fibroblasts exposed to 5-aza-cytidine (5-aza-CR), an inhibit...
Somatic embryogenesis (SE) is a widely studied process due to its biotechnological potential to gene...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
Covalent modification of DNA distinguishes cellular identities and is crucial for regulating the plu...