Pathogenic mycobacteria use virulence factors, including mannose-capped lipoarabinomannan (ManLAM), to survive in host phagocytic cells, such as neutrophils. We assessed the roles of lactosylceramide (LacCer, CDw17)-enriched lipid rafts in the phagocytosis of mycobacteria by human neutrophils and in the intracellular fate of phagocytosed mycobacteria. We showed that the association of the Src family kinase (SFK) Lyn with C24 fatty acid chain-containing LacCer was essential for the phagocytosis of mycobacteria by neutrophils. Assays with LacCer-containing liposomes, LacCer-coated plastic plates, and LAM-coated beads demonstrated that the phagocytosis of mycobacteria was mediated through the binding of LacCer to LAM. Both ManLAM from pathogen...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
AbstractTuberculosis is an infectious and potentially fatal disease caused by the acid-fast bacillus...
Lipoarabinomannans (LAMs) are major lipoglycans of the mycobacterial envelope and constitute immunod...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen persisting in phagosomes that has th...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
AbstractTuberculosis is an infectious and potentially fatal disease caused by the acid-fast bacillus...
Lipoarabinomannans (LAMs) are major lipoglycans of the mycobacterial envelope and constitute immunod...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen persisting in phagosomes that has th...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as one of the key v...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune s...
AbstractTuberculosis is an infectious and potentially fatal disease caused by the acid-fast bacillus...