Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis
International audienceLung cancer is the end result of a multistep process in which genetic and mole...
We examined the preneoplastic nature of atypical adenomatous hyperplasia (AAH) of the lung by compar...
Lung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcin...
To assess the multiple steps involved in carcinogenesis we evaluated p53 gene mutation frequencies, ...
Alterations of p53 are one of the most common molecular changes found in all types of lung tumors, s...
Mutation of one p53 allele and loss of the normal p53 allele [loss of heterozygosity (LOH)] occur in...
Squamous cell carcinoma (SQCC) of the lung is thought to arise after the accumulation of multiple mu...
In an attempt to define the type and temporal sequences of somatic genetic changes that precede the ...
I examined 15 cases of differentiated adenocarcinoma of the lung which showed mutation of the p53 ge...
Although the short arm of chromosome 17, which contains the p53 gene, is frequently affected by loss...
Patients with a primary cancer in the lung or in the upper aerodigestive tract have an increased ris...
International audienceBronchial and bronchioloalveolar carcinogenesis is a multicentric and multiste...
International audiencep53 mutations and myc gene amplification and expression were studied in 119 lu...
PubMedID: 20444664Background: Chromosomal aberrations and instability of gene(s) are two factors rel...
Mutations in the p53 tumour suppressor gene, with consequent accumulation of the p53 protein, are fr...
International audienceLung cancer is the end result of a multistep process in which genetic and mole...
We examined the preneoplastic nature of atypical adenomatous hyperplasia (AAH) of the lung by compar...
Lung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcin...
To assess the multiple steps involved in carcinogenesis we evaluated p53 gene mutation frequencies, ...
Alterations of p53 are one of the most common molecular changes found in all types of lung tumors, s...
Mutation of one p53 allele and loss of the normal p53 allele [loss of heterozygosity (LOH)] occur in...
Squamous cell carcinoma (SQCC) of the lung is thought to arise after the accumulation of multiple mu...
In an attempt to define the type and temporal sequences of somatic genetic changes that precede the ...
I examined 15 cases of differentiated adenocarcinoma of the lung which showed mutation of the p53 ge...
Although the short arm of chromosome 17, which contains the p53 gene, is frequently affected by loss...
Patients with a primary cancer in the lung or in the upper aerodigestive tract have an increased ris...
International audienceBronchial and bronchioloalveolar carcinogenesis is a multicentric and multiste...
International audiencep53 mutations and myc gene amplification and expression were studied in 119 lu...
PubMedID: 20444664Background: Chromosomal aberrations and instability of gene(s) are two factors rel...
Mutations in the p53 tumour suppressor gene, with consequent accumulation of the p53 protein, are fr...
International audienceLung cancer is the end result of a multistep process in which genetic and mole...
We examined the preneoplastic nature of atypical adenomatous hyperplasia (AAH) of the lung by compar...
Lung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcin...