Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients

Purpose: Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil. Methods: Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe1, ProRe2), with the same sedation targets. Results: With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe1: respectively, 3.3 \ub1 3.0 versus 8.9 \ub1 6.1 and 7.47 \ub1 5.05 versus 16.3 \ub1 11.4 min. During SevAn the PaCO2 and minute ventilation increased. Hemodynamics was stable between ProRe1 and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits. Conclusions: Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions