Cell therapy is one promising approach to correct genetic diseases by contributing to tissue regeneration; stem cells can be isolated from a healthy donor or, when possible from the same patient. In the first case cells will be transplanted under a regime of immune suppression while in the second case, cells will have to be genetically corrected before transplantation in the same patient from which they were derived. The overall objective of our work is the validation of a clinical treatment for patients affected by Duchenne muscular dystrophy. The project does the groundwork for a phase I/II clinical trial consisting of an intramuscular transplantation of autologous CD133+ stem cells after their engineering through a lentiviral vector. The...
Genetic mutations in muscle structural genes can compromise myofiber integrity, causing repeated mus...
Duchenne Muscular Dystrophy is a lethal X-linked recessive disorder caused by deficiency of the prot...
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive muscle disease due to defect on the...
Cell therapy is one promising approach to correct genetic diseases by contributing to tissue regener...
Cell therapy is one promising approach to correct genetic diseases by contributing to tissue regener...
PROBLEM Muscular dystrophies are a heterogeneous group of inherited disorders presenting a large cli...
PROBLEM Muscular dystrophies are a heterogeneous group of inherited disorders presenting a large cli...
Cell therapy is one promising approach to correct genetic diseases by contributing to tissue regener...
This chapter focuses on stem cell-based therapies to treat muscular dystrophy. It reviews previous ...
This chapter focuses on stem cell-based therapies to treat muscular dystrophy. It reviews previous ...
Muscular dystrophies are heritable, heterogeneous neuromuscular disorders and include Duchenne and B...
This chapter focuses on stem cell-based therapies to treat muscular dystrophy. It reviews previous a...
Duchenne muscular dystrophy (DMD) is a lethal muscle disease for which an effective treatment is urg...
Duchenne muscular dystrophy (DMD) is a lethal muscle disease for which an effective treatment is urg...
Mutations in the dystrophin gene cause an X-linked genetic disorder: Duchenne muscular dystrophy (DM...
Genetic mutations in muscle structural genes can compromise myofiber integrity, causing repeated mus...
Duchenne Muscular Dystrophy is a lethal X-linked recessive disorder caused by deficiency of the prot...
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive muscle disease due to defect on the...
Cell therapy is one promising approach to correct genetic diseases by contributing to tissue regener...
Cell therapy is one promising approach to correct genetic diseases by contributing to tissue regener...
PROBLEM Muscular dystrophies are a heterogeneous group of inherited disorders presenting a large cli...
PROBLEM Muscular dystrophies are a heterogeneous group of inherited disorders presenting a large cli...
Cell therapy is one promising approach to correct genetic diseases by contributing to tissue regener...
This chapter focuses on stem cell-based therapies to treat muscular dystrophy. It reviews previous ...
This chapter focuses on stem cell-based therapies to treat muscular dystrophy. It reviews previous ...
Muscular dystrophies are heritable, heterogeneous neuromuscular disorders and include Duchenne and B...
This chapter focuses on stem cell-based therapies to treat muscular dystrophy. It reviews previous a...
Duchenne muscular dystrophy (DMD) is a lethal muscle disease for which an effective treatment is urg...
Duchenne muscular dystrophy (DMD) is a lethal muscle disease for which an effective treatment is urg...
Mutations in the dystrophin gene cause an X-linked genetic disorder: Duchenne muscular dystrophy (DM...
Genetic mutations in muscle structural genes can compromise myofiber integrity, causing repeated mus...
Duchenne Muscular Dystrophy is a lethal X-linked recessive disorder caused by deficiency of the prot...
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive muscle disease due to defect on the...