Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer
- O. De Cobelli
- C. Buonerba
- D. Terracciano
- B. Danilo
- L. Giuseppe
- P. Bove
- V. Altieri
- I. Coman
- S. Perdonà
- G. Facchini
- M. Berretta
- G.D. Lorenzo
- P. Grieco
- E. Novellino
- R. Franco
- M. Caraglia
- C. Manini
- V. Mirone
- S.D. Placido
- G. Sonpavde
- M. Ferro
DOIAbstract
Aim: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients. Methods: A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry. Results: A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55\u201368.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23\u2013100.48). Conclusions: UTII-R expression on biopsy was asso...
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