The complex flavonoid montbretin A (MbA) is a powerful inhibitor of human pancreatic amylase (HPA) and a potential tool in the treatment of type 2 diabetes. The X-ray structure of the MbA\u2013HPA complex now shows that a hydrophobic collapse of two phenol fragments in the structure of MbA is key to its activity
SUMMARYAlpha amylase inhibitors affect carbohydrate metabolism in digestive system. The inhibitors i...
Human pancreatic α-amylase (HPA), situated at the apex of the starch digestion hierarchy, is an attr...
Aldose reductase (AR), α-amylase, and α-glycosidase are vital enzymes to prevent diabetic complicati...
The increasing prevalence of type 2 diabetes has stimulated research aimed at discovering new drugs ...
Human pancreatic alpha-amylase (HPA) is the enzyme responsible for hydrolyzing starch within the gut...
Type 2 diabetes (T2D) is characterised by hyperglycaemia resulting from defective insulin secretion,...
Human pancreatic α-amylase (HPA) catalyzes a key step in the degradation of ingested starch. Accordi...
Type 2 diabetes and Alzheimer’s disease are closely related amyloid diseases globally affecting mill...
Montbretins A-E were isolated from the corms of Crocosmia sp., an invasive perennial plant. The mont...
In this study, structural specificity of flavonoids was investigated to selectively inhibit starch d...
α-Amylase has been considered an important therapeutic target for the management of type 2 diabetes ...
Human Amylin, or islet amyloid polypeptide (hIAPP), is a small hormone secreted by pancreatic-cells ...
Background: Diabetes mellitus (DM) is a serious public health challenge, projected by WHO to be one ...
Background: α-Amylase plays an important role in starch digestion, the main source of exogenous gluc...
Introduction: The increasing prevalence of type 2 diabetes mellitus and the negative clinical outcom...
SUMMARYAlpha amylase inhibitors affect carbohydrate metabolism in digestive system. The inhibitors i...
Human pancreatic α-amylase (HPA), situated at the apex of the starch digestion hierarchy, is an attr...
Aldose reductase (AR), α-amylase, and α-glycosidase are vital enzymes to prevent diabetic complicati...
The increasing prevalence of type 2 diabetes has stimulated research aimed at discovering new drugs ...
Human pancreatic alpha-amylase (HPA) is the enzyme responsible for hydrolyzing starch within the gut...
Type 2 diabetes (T2D) is characterised by hyperglycaemia resulting from defective insulin secretion,...
Human pancreatic α-amylase (HPA) catalyzes a key step in the degradation of ingested starch. Accordi...
Type 2 diabetes and Alzheimer’s disease are closely related amyloid diseases globally affecting mill...
Montbretins A-E were isolated from the corms of Crocosmia sp., an invasive perennial plant. The mont...
In this study, structural specificity of flavonoids was investigated to selectively inhibit starch d...
α-Amylase has been considered an important therapeutic target for the management of type 2 diabetes ...
Human Amylin, or islet amyloid polypeptide (hIAPP), is a small hormone secreted by pancreatic-cells ...
Background: Diabetes mellitus (DM) is a serious public health challenge, projected by WHO to be one ...
Background: α-Amylase plays an important role in starch digestion, the main source of exogenous gluc...
Introduction: The increasing prevalence of type 2 diabetes mellitus and the negative clinical outcom...
SUMMARYAlpha amylase inhibitors affect carbohydrate metabolism in digestive system. The inhibitors i...
Human pancreatic α-amylase (HPA), situated at the apex of the starch digestion hierarchy, is an attr...
Aldose reductase (AR), α-amylase, and α-glycosidase are vital enzymes to prevent diabetic complicati...
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