Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy
- H.A. Azim
- A. Vingiani
- F. Peccatori
- G. Viale
- S. Loi
- G. Pruneri
DOIAbstract
Background: Tumour infiltrating lymphocytes (TILs) is one of the most exciting breast cancer biomarkers, yet no data is available on its prevalence in tumours diagnosed during pregnancy. Methods: We evaluated the prevalence of TILs (stromal and intratumoural) in pregnant and non-pregnant young breast cancer patients. Results: 11/116 (9.6%) of the non-pregnant and 2/86 (2.3%) pregnant patients had TILs 6550% (p<0.001) with highest prevalence observed in triple negative tumours (p=0.01). Conclusions: This is the first report on TILs in tumours diagnosed during pregnancy. The low prevalence could reflect the state of low host immunity associated with pregnancy
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