Add to ORKGerythrocytic stages of Plasmodium falciparum (P.f.) (IC50 <10 nM) but the molecular target is unknown and preliminary results indicate that these compounds may exert their activities against P.f. through multiple targets. Proteomics offers a unique tool for target identification and several proteomic approaches are available, one of the most interesting is the so called chemical proteomics, which couple affinity purification methods with mass spectrometry and therefore permits to increase selectivity and sensitivity. Several limitations can affect the results of chemical proteomics approaches, for example, it is necessary to use tag compounds that present high activity and affinity for the target protein. Moreover, considering that LC-MS a...
Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation o...
Malaria is a parasitic disease caused by protozoan parasites of the genus Plasmodium. The World Heal...
AbstractThe need for new antimalarials is persistent due to the emergence of drug resistant parasite...
We have previously identified new compounds with high in vitro efficacies against the intraerythroc...
We have previously identified new compounds with high in vitro efficacies against the intraerythrocy...
<div><p><i>Plasmodium falciparum</i> is responsible for severe malaria which is one of the most prev...
Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to id...
The parasite Plasmodium falciparum is the main agent responsible for malaria. In this study, we expl...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Previously held under moratorium in Chemistry Department (GSK) from 17/06/2020 to 23/11/2022.The con...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
There is no effective vaccine against malaria; therefore, chemotherapy is to date the only choice to...
Malaria causes about half a million deaths annually, with Plasmodium falciparum being responsible fo...
The need for new antimalarials is persistent due to the emergence of drug resistant parasites. Here ...
Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation o...
Malaria is a parasitic disease caused by protozoan parasites of the genus Plasmodium. The World Heal...
AbstractThe need for new antimalarials is persistent due to the emergence of drug resistant parasite...
We have previously identified new compounds with high in vitro efficacies against the intraerythroc...
We have previously identified new compounds with high in vitro efficacies against the intraerythrocy...
<div><p><i>Plasmodium falciparum</i> is responsible for severe malaria which is one of the most prev...
Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to id...
The parasite Plasmodium falciparum is the main agent responsible for malaria. In this study, we expl...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Previously held under moratorium in Chemistry Department (GSK) from 17/06/2020 to 23/11/2022.The con...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
There is no effective vaccine against malaria; therefore, chemotherapy is to date the only choice to...
Malaria causes about half a million deaths annually, with Plasmodium falciparum being responsible fo...
The need for new antimalarials is persistent due to the emergence of drug resistant parasites. Here ...
Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation o...
Malaria is a parasitic disease caused by protozoan parasites of the genus Plasmodium. The World Heal...
AbstractThe need for new antimalarials is persistent due to the emergence of drug resistant parasite...