Add to ORKGWe have previously identified new compounds with high in vitro efficacies against the intraerythrocytic stages of Plasmodium falciparum (P.f.) (IC50 <10 nM), but the molecular target is unknown and preliminary results indicate that indeed multiple targets may exists.(1-4) Proteomics offers a unique tool for target identification and several proteomic approaches are available. One of the most interesting is the so called \u201cchemical proteomics\u201d, which couples affinity purification methods with mass spectrometry and therefore permits to increase selectivity and sensitivity. Several limitations can affect the results of chemical proteomics approaches. For example, it is necessary to use tag compounds that present high activity and affi...
Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation o...
Malaria is a parasitic disease caused by protozoan parasites of the genus Plasmodium. The World Heal...
Plasmodium falciparum is the protozoan parasite that is the causative agent of malaria in humans. Th...
We have previously identified new compounds with high in vitro efficacies against the intraerythroc...
<div><p><i>Plasmodium falciparum</i> is responsible for severe malaria which is one of the most prev...
Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to id...
The parasite Plasmodium falciparum is the main agent responsible for malaria. In this study, we expl...
There is no effective vaccine against malaria; therefore, chemotherapy is to date the only choice to...
Malaria causes about half a million deaths annually, with Plasmodium falciparum being responsible fo...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
AbstractThe need for new antimalarials is persistent due to the emergence of drug resistant parasite...
The need for new antimalarials is persistent due to the emergence of drug resistant parasites. Here ...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Previously held under moratorium in Chemistry Department (GSK) from 17/06/2020 to 23/11/2022.The con...
Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation o...
Malaria is a parasitic disease caused by protozoan parasites of the genus Plasmodium. The World Heal...
Plasmodium falciparum is the protozoan parasite that is the causative agent of malaria in humans. Th...
We have previously identified new compounds with high in vitro efficacies against the intraerythroc...
<div><p><i>Plasmodium falciparum</i> is responsible for severe malaria which is one of the most prev...
Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to id...
The parasite Plasmodium falciparum is the main agent responsible for malaria. In this study, we expl...
There is no effective vaccine against malaria; therefore, chemotherapy is to date the only choice to...
Malaria causes about half a million deaths annually, with Plasmodium falciparum being responsible fo...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
AbstractThe need for new antimalarials is persistent due to the emergence of drug resistant parasite...
The need for new antimalarials is persistent due to the emergence of drug resistant parasites. Here ...
Plasmodium falciparum is a protozoan parasite and the causative agent of malaria, which kills upward...
Previously held under moratorium in Chemistry Department (GSK) from 17/06/2020 to 23/11/2022.The con...
Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation o...
Malaria is a parasitic disease caused by protozoan parasites of the genus Plasmodium. The World Heal...
Plasmodium falciparum is the protozoan parasite that is the causative agent of malaria in humans. Th...