This open-label, single centre pilot study was designed to evaluate safety and tolerability of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a non steroid anti-inflammatory drug, in a cohort of adult dystrophic patients (Duchenne, Becker and Limb-Girdle Muscular Dystrophy). Seventy-one patients were recruited: 35, treated with the drug combination for 12 months, and 36 untreated. Safety and adverse events were assessed by reported signs and symptoms, physical examinations, blood tests, cardiac and respiratory function tests. Exploratory outcomes measure, such as the motor function measure scale, were also applied. Good safety and tolerability profiles of the long-term co-administration of the drugs ...
Introduction: Glucocorticoids are the only drugs available for the treatment of Duchenne muscular dy...
Background: Nutritional compounds can exert both anti-inflammatory and anti-oxidant effects. Since t...
SummaryBackgroundWe report clinical safety and biochemical efficacy from a dose-ranging study of int...
BACKGROUND AND PURPOSE: Current therapies for muscular dystrophy are based on corticosteroids. Signi...
We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and...
A resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases leading to ...
Duchenne muscular dystrophy is a relatively common disease that affects skeletal muscle, leading to ...
Importance:Nitric oxide precursors, such as the amino acid l-arginine and the biguanide antidiabetic...
Importance: Nitric oxide precursors, such as the amino acid l-arginine and the biguanide antidiabeti...
Duchenne muscular dystrophy (DMD) is a degenerative disease primarily affecting voluntary muscles wi...
AbstractA resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases lea...
In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystroph...
In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystroph...
<div><p>In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, ...
Background: In dystrophin-deficient muscles of Duchenne Muscular Dystrophy (DMD) patients and the md...
Introduction: Glucocorticoids are the only drugs available for the treatment of Duchenne muscular dy...
Background: Nutritional compounds can exert both anti-inflammatory and anti-oxidant effects. Since t...
SummaryBackgroundWe report clinical safety and biochemical efficacy from a dose-ranging study of int...
BACKGROUND AND PURPOSE: Current therapies for muscular dystrophy are based on corticosteroids. Signi...
We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and...
A resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases leading to ...
Duchenne muscular dystrophy is a relatively common disease that affects skeletal muscle, leading to ...
Importance:Nitric oxide precursors, such as the amino acid l-arginine and the biguanide antidiabetic...
Importance: Nitric oxide precursors, such as the amino acid l-arginine and the biguanide antidiabeti...
Duchenne muscular dystrophy (DMD) is a degenerative disease primarily affecting voluntary muscles wi...
AbstractA resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases lea...
In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystroph...
In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystroph...
<div><p>In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, ...
Background: In dystrophin-deficient muscles of Duchenne Muscular Dystrophy (DMD) patients and the md...
Introduction: Glucocorticoids are the only drugs available for the treatment of Duchenne muscular dy...
Background: Nutritional compounds can exert both anti-inflammatory and anti-oxidant effects. Since t...
SummaryBackgroundWe report clinical safety and biochemical efficacy from a dose-ranging study of int...