Breast conservative surgery for well-differentiated ductal intraepithelial neoplasia : risk factors for ipsilateral breast tumor recurrence
- A. Toesca
- E. Botteri
- M. Lazzeroni
- J. Vila
- A. Manika
- B. Ballardini
- F. Bettarini
- A. Guerrieri-Gonzaga
- B. Bonanni
- N. Rotmensz
- G. Viale
- P. Veronesi
- A. Luini
- U. Veronesi
- O. Gentilini
DOIAbstract
Rational: We retrospectively analyzed 232 patients affected by well differentiated ductal intraepithelial neoplasia (DIN1c or DCIS G1) treated with conservative surgery without adjuvant radiotherapy. Results: 25 invasive and 18 non-invasive local recurrences were observed ( median follow-up 80 months; 5-year cumulative incidence: 12.2%). Seven of the 15 young patients ( 7% (HR 2.33, 95% C.I. 1.20-4.55) and surgical margins <10 mm (HR 2.00, 95% C.I. 1.06-3.76) were significantly associated with an increased risk of local recurrence. Conclusions: Young age, multifocality and small margins appeared as clear risk factors of local recurrence in DIN1c (DCIS G1) population. The presence of multiple poor prognostic features warrant a thorough dis...
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