The sponge-derived macrolide (-)-dictyostatin (1) has been reported to exhibit paclitaxel-like effects on cellular microtubules and to inhibit human cancer cell proliferation (even of paclitaxel-resistant cancer cell lines) at low nanomolar concentrations, with activity somewhat superior to the already very active discodermolide.1 Although four total syntheses of (-)-dictyostatin were recently completed,2 the development of a practical and flexible synthesis remains an important goal, particularly as its natural supply is extremely scarce. Here we report a highly stereoselective total synthesis of (-)-dictyostatin, achived by coupling two key-fragments,3 C1-C9 (2) and C10-C26 (3), followed by Yamaguchi macrolactonization and global deprote...
The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established th...
The natural product ()-dictyostatin is a microtubule-stabilizing agent that potently inhibits the gr...
Abstract: The efficient synthesis of the C1–C10 fragment of (–)-dictyostatin has been achieved by Ev...
The sponge-derived macrolide (-)-dictyostatin (1) has been reported to exhibit paclitaxel-like effec...
(-)-Dictyostatin, isolated from a marine sponge, shows potent cancer cell antiproliferative activity...
Since the discovery from the Pacific Yew Tree in 1971, paclitaxel (Taxol ®) has been a matter of kee...
The total syntheses of (+)-9-epi-dictyostatin (1a) and (-)-12,13-bis-epi-dictyostatin (1b), diastere...
Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin, and a...
The marine sponge-derived antimitotic polyketides discodermolide (12) and dictyostatin (16) are impo...
Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin and a ...
The dictyostatins are a promising class of potential anti-cancer drugs because they are powerful mic...
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative acti...
The total synthesis of (+)-9-epi-dictyostatin (1b), a diastereomer of the antimitotic marine-sponge-...
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative acti...
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative acti...
The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established th...
The natural product ()-dictyostatin is a microtubule-stabilizing agent that potently inhibits the gr...
Abstract: The efficient synthesis of the C1–C10 fragment of (–)-dictyostatin has been achieved by Ev...
The sponge-derived macrolide (-)-dictyostatin (1) has been reported to exhibit paclitaxel-like effec...
(-)-Dictyostatin, isolated from a marine sponge, shows potent cancer cell antiproliferative activity...
Since the discovery from the Pacific Yew Tree in 1971, paclitaxel (Taxol ®) has been a matter of kee...
The total syntheses of (+)-9-epi-dictyostatin (1a) and (-)-12,13-bis-epi-dictyostatin (1b), diastere...
Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin, and a...
The marine sponge-derived antimitotic polyketides discodermolide (12) and dictyostatin (16) are impo...
Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin and a ...
The dictyostatins are a promising class of potential anti-cancer drugs because they are powerful mic...
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative acti...
The total synthesis of (+)-9-epi-dictyostatin (1b), a diastereomer of the antimitotic marine-sponge-...
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative acti...
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative acti...
The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established th...
The natural product ()-dictyostatin is a microtubule-stabilizing agent that potently inhibits the gr...
Abstract: The efficient synthesis of the C1–C10 fragment of (–)-dictyostatin has been achieved by Ev...