Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a nuclear protein with controversial effects on cancer cells and with important roles in the regulation of apoptosis, transcription and histones modifications. Previously, we reported that, in response to DNA damage, ATM and ATR phosphorylate DBC1 on T454, promoting the inhibition of the NAD+ dependent deacetylase SIRT1 and, finally, inducing p53 acetylation and apoptosis. We deepen characterized the molecular mechanism by which DBC1 inhibits SIRT1 and found that, beside ATM/ATR, the DBC1-dependent inhibition of SIRT1 requires also the checkpoint kinase Chk2 and the 11S proteasome activator REG\u3b3. Specifically, in response to etoposide Chk2 phosphorylates REG\u3b3 promoting DBC1...
Deleted in breast cancer-1 (DBC1) contributes to the regulation of cell survival and apoptosis. Rece...
Deleted in breast cancer-1 (DBC1) contributes to the regu-lation of cell survival and apoptosis. Rec...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a protein implicated in the regulation o...
Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a protein implicated in the regulation o...
Human DBC1 (Deleted in Breast Cancer-1; KIAA1967) is a nuclear protein involved in apoptosis, transc...
Human DBC1 (deleted in breast cancer-1; KIAA1967) is a nuclear protein that, in response to DNA dama...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
The NAD-dependent deacetylase SirT1 regulates gene silencing and genomic stability in response to nu...
BACKGROUND: DBC1/KIAA1967 (deleted in breast cancer 1) is a putative tumour-suppressor gene cloned f...
The cellular DNA damage response (DDR) is initiated by the rapid recruitment of repair factors to th...
Cyclin-dependent kinases (Cdks) promote cellular proliferation, are often deregulated in human cance...
DNA damage is a key factor both in the evolution and treatment of cancer. Genomic instability is a c...
DNA damage response (DDR) pathways are triggered to ensure proper repair of DNA lesions and preserve...
SummaryDBC1 (deleted in breast cancer 1), also known as CCAR2 or KIAA1967, is an important negative ...
Deleted in breast cancer-1 (DBC1) contributes to the regulation of cell survival and apoptosis. Rece...
Deleted in breast cancer-1 (DBC1) contributes to the regu-lation of cell survival and apoptosis. Rec...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a protein implicated in the regulation o...
Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a protein implicated in the regulation o...
Human DBC1 (Deleted in Breast Cancer-1; KIAA1967) is a nuclear protein involved in apoptosis, transc...
Human DBC1 (deleted in breast cancer-1; KIAA1967) is a nuclear protein that, in response to DNA dama...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
The NAD-dependent deacetylase SirT1 regulates gene silencing and genomic stability in response to nu...
BACKGROUND: DBC1/KIAA1967 (deleted in breast cancer 1) is a putative tumour-suppressor gene cloned f...
The cellular DNA damage response (DDR) is initiated by the rapid recruitment of repair factors to th...
Cyclin-dependent kinases (Cdks) promote cellular proliferation, are often deregulated in human cance...
DNA damage is a key factor both in the evolution and treatment of cancer. Genomic instability is a c...
DNA damage response (DDR) pathways are triggered to ensure proper repair of DNA lesions and preserve...
SummaryDBC1 (deleted in breast cancer 1), also known as CCAR2 or KIAA1967, is an important negative ...
Deleted in breast cancer-1 (DBC1) contributes to the regulation of cell survival and apoptosis. Rece...
Deleted in breast cancer-1 (DBC1) contributes to the regu-lation of cell survival and apoptosis. Rec...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...