A geometric index to differentiate abnormal from normal septal wall motion on cardiac MRI

BACKGROUND: The definition of abnormal septal wall motion (SWM) is usually performed on a subjective visual assessment with cardiac MR (CMR). PURPOSE: To quantify SWM using a geometric index and to compare this index to the visual inspection in patients with or without abnormal SWM. MATERIAL AND METHODS: Cine CMR images of 100 consecutive patients were retrospectively assessed for visual evaluation of SWM and calculation of a convexity septal index (CSI) on mid-ventricular short-axis images, defined as b/a (a\u2009=\u2009minimal distance from anterior to posterior ventricular junctions; b\u2009=\u2009maximal distance from septum to a), obtained in end-systole (ES) and end-diastole (ED). Cohen \u3ba, Bland-Altman method, Kruskall-Wallis, Mann-Whitney U, Jonckheere-Terpstra, and Spearman statistics were used to compare the two methods. RESULTS: At visual evaluation, 73 patients had normal SWM (group A), nine abnormal SWM at ES (group B), and 18 at ES and ED (group C). Median CSI for group A was significantly higher (ES\u2009=\u20090.23, ED\u2009=\u20090.25) than those for group B and C (0.10-0.15) (P\u2009<\u20090.001). Inter-reader reproducibility of visual evaluation was high (\u3ba\u2009=\u20090.841, P\u2009<\u20090.001) while that for CSI was 77%. Average time for visual analysis was 3\u2009min, for quantitative analysis 4\u2009min. CONCLUSION: CSI is a simple and reproducible way to quantify SWM. ED CSI seems to be sensitive in detecting abnormal SWM in patients with apparently normal SWM at visual evaluation