To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respectively of type I, II and III. FUS-CHOP binding to the promoters of some target genes such as Pentraxin 3 or Fibronectin 1, assessed by chromatin immunoprecipitation, was strongly reduced in the tumor 24 h after the first or the third weekly dose of trabectedin, indicating that the drug at therapeutic doses causes a detachment of the FUS-CHOP chimera from its target promoters as previously shown in vitro. Moreover, the higher sen...
Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered...
Trabectedin is a marine natural product, approved in Europe for the treatment of soft tissue sarcoma...
Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effec...
To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to t...
Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes...
Trabectedin (ET-743, Yondelis) is a marine alkaloid isolated from the tunicate Ecteinascidia turbina...
Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes...
Myxoid liposarcoma (MLPS) is a rare soft-tissue sarcoma characterised by the expression of FUS-DDIT3...
Trabectedin (ET-743, Yondelis) is a marine alkaloid isolated from the tunicate Ecteinascidia turbina...
Myxoid Liposarcomas (MLS), characterized by the expression of FUS-CHOP fusion gene are clinically ve...
Myxoid Liposarcomas (MLS), characterized by the expression of FUS-CHOP fusion gene are clinically ve...
Purpose: Myxoid liposarcoma is a common subtype of liposarcoma. It is associated in more than 90% of...
This record contains data related to article "Mechanisms of responsiveness to and resistance against...
Among soft tissue sarcomas, myxoid liposarcomas are exceedingly sensitive to trabectedin. Obvious tu...
Myxoid liposarcoma (MLPS) is a rare soft tissue sarcoma of the mesenchymal cells characterised by th...
Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered...
Trabectedin is a marine natural product, approved in Europe for the treatment of soft tissue sarcoma...
Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effec...
To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to t...
Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes...
Trabectedin (ET-743, Yondelis) is a marine alkaloid isolated from the tunicate Ecteinascidia turbina...
Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes...
Myxoid liposarcoma (MLPS) is a rare soft-tissue sarcoma characterised by the expression of FUS-DDIT3...
Trabectedin (ET-743, Yondelis) is a marine alkaloid isolated from the tunicate Ecteinascidia turbina...
Myxoid Liposarcomas (MLS), characterized by the expression of FUS-CHOP fusion gene are clinically ve...
Myxoid Liposarcomas (MLS), characterized by the expression of FUS-CHOP fusion gene are clinically ve...
Purpose: Myxoid liposarcoma is a common subtype of liposarcoma. It is associated in more than 90% of...
This record contains data related to article "Mechanisms of responsiveness to and resistance against...
Among soft tissue sarcomas, myxoid liposarcomas are exceedingly sensitive to trabectedin. Obvious tu...
Myxoid liposarcoma (MLPS) is a rare soft tissue sarcoma of the mesenchymal cells characterised by th...
Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered...
Trabectedin is a marine natural product, approved in Europe for the treatment of soft tissue sarcoma...
Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effec...