The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal
AbstractConditions that partially inhibit DNA replication induce expression of common fragile sites....
he ability of cells to respond to DNA damage and to stalled DNA replica-tion forks is essential for ...
Defects in chromosome replication can lead to translocations that are thought to result from recombi...
The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing t...
SummaryWhen replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase...
When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase checkp...
During S-phase, the genome is extremely vulnerable and the progression of replication forks is often...
Genome maintenance is required for cellular viability, and failure to preserve genomic integrity is ...
Problems during DNA replication often cause chromosomal abnormalities when replication forks become ...
Replication fork stalling frequently occurs during DNA replication in eukaryotic cells and destabili...
SummaryTranscription hinders replication fork progression and stability, and the Mec1/ATR checkpoint...
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protec...
Summary: Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that a...
Checkpoints were originally identified as signalling pathways that delay mitosis in response to DNA ...
How dividing mammalian cells overcome blocks to DNA replication by DNA damage, depleted nucleotide p...
AbstractConditions that partially inhibit DNA replication induce expression of common fragile sites....
he ability of cells to respond to DNA damage and to stalled DNA replica-tion forks is essential for ...
Defects in chromosome replication can lead to translocations that are thought to result from recombi...
The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing t...
SummaryWhen replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase...
When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase checkp...
During S-phase, the genome is extremely vulnerable and the progression of replication forks is often...
Genome maintenance is required for cellular viability, and failure to preserve genomic integrity is ...
Problems during DNA replication often cause chromosomal abnormalities when replication forks become ...
Replication fork stalling frequently occurs during DNA replication in eukaryotic cells and destabili...
SummaryTranscription hinders replication fork progression and stability, and the Mec1/ATR checkpoint...
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protec...
Summary: Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that a...
Checkpoints were originally identified as signalling pathways that delay mitosis in response to DNA ...
How dividing mammalian cells overcome blocks to DNA replication by DNA damage, depleted nucleotide p...
AbstractConditions that partially inhibit DNA replication induce expression of common fragile sites....
he ability of cells to respond to DNA damage and to stalled DNA replica-tion forks is essential for ...
Defects in chromosome replication can lead to translocations that are thought to result from recombi...
DOI
Add to ORKG