WHO recommends to avoid artemisinin treatment during the first trimester of pregnancy, because animal models showed a significant depletion of embryonic red cells, which occurs only during a specific days of gestation. We recently demonstrated for the first time that DHA, which is the in vivo metabolite of many artemisinin derivatives, inhibits human erythroid cell differentiation, as well. We showed that DHA specifically targets the pro and basophilic erythroblasts during in vitro erythroid cell differentiation of CD34+ stem cells. By using K562 cells differentiated toward the erythroid lineages by chemical inducers and by comparing the effects of several artemisinins, we confirmed that DHA is the most toxic compound of this drug family. S...
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiprolif...
The sesquiterpene lactone dihydroartemisinin (DHA), a drug artemisinin, is cytotoxic to human tumor ...
Artemisinin derivatives, the current cornerstone of malaria treatment, possess also anti-angiogenic ...
Artemisinin derivatives such as dihydroartemisinin (DHA) induce significant depletion of early embry...
Artemisinins are safely used in the combination therapy for uncomplicated malaria, but their employm...
Artemisinins are safely used in the combination therapy for uncomplicated malaria, but their employm...
Women in their first pregnancy are at the very high-risk of developing severe malaria which includes...
BACKGROUND: Severe malaria in pregnancy causes maternal anemia, low birth weight increased mortality...
Objectives: WHO does not recommend the use of Artemisinin Combination Therapy (ACT) to treat malaria...
Artemisinin derivatives are very active and safe antimalarials, presently used in several therapeut...
Artemisinin derivatives are widely used in combination with quinolines and antifolates antimalarials...
AbstractDihydroartemisinin (DHA), an active metabolite of artemisinin derivatives, is the most remar...
Despite recent advances in chemotherapy and surgical resection, the 5-year survival rate of esophage...
AbstractDihydroartemisinin (DHA), an active metabolite of artemisinin derivatives, is the most remar...
Artemisinin derivatives are the most effective and safe antimalarial drugs available. They possess a...
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiprolif...
The sesquiterpene lactone dihydroartemisinin (DHA), a drug artemisinin, is cytotoxic to human tumor ...
Artemisinin derivatives, the current cornerstone of malaria treatment, possess also anti-angiogenic ...
Artemisinin derivatives such as dihydroartemisinin (DHA) induce significant depletion of early embry...
Artemisinins are safely used in the combination therapy for uncomplicated malaria, but their employm...
Artemisinins are safely used in the combination therapy for uncomplicated malaria, but their employm...
Women in their first pregnancy are at the very high-risk of developing severe malaria which includes...
BACKGROUND: Severe malaria in pregnancy causes maternal anemia, low birth weight increased mortality...
Objectives: WHO does not recommend the use of Artemisinin Combination Therapy (ACT) to treat malaria...
Artemisinin derivatives are very active and safe antimalarials, presently used in several therapeut...
Artemisinin derivatives are widely used in combination with quinolines and antifolates antimalarials...
AbstractDihydroartemisinin (DHA), an active metabolite of artemisinin derivatives, is the most remar...
Despite recent advances in chemotherapy and surgical resection, the 5-year survival rate of esophage...
AbstractDihydroartemisinin (DHA), an active metabolite of artemisinin derivatives, is the most remar...
Artemisinin derivatives are the most effective and safe antimalarial drugs available. They possess a...
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiprolif...
The sesquiterpene lactone dihydroartemisinin (DHA), a drug artemisinin, is cytotoxic to human tumor ...
Artemisinin derivatives, the current cornerstone of malaria treatment, possess also anti-angiogenic ...