Add to ORKGAs centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These finding...
The degenerative processes that occur during aging increase the risk of disease and impaired health....
As ageing is a major risk factor for the development of non-communicable diseases, extending healths...
Understanding the complexity of aging is of utmost importance. This can now be addressed by the nove...
As centenarians well represent the model of healthy aging, there are many important implications in ...
As centenarians well represent the model of healthy aging, there are many important implications in ...
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable...
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable...
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. ...
Sphingolipids (SLs) are structural components of the lipid bilayer regulating cell functions. In bio...
Aging is a multifaceted process involving the accumulation of diverse deleterious changes in biologi...
As centenarians provide a paradigm of healthy aging, investigating the comprehensive metabolic profi...
Aging process is characterized by a progressive decline of several organic, physiological, and metab...
Organism aging is closely related to systemic metabolic changes. However, due to the multilevel and ...
Advancing age is associated with declines across numerous physiological systems, leading to an incre...
Middle-aged offspring of nonagenarians, as compared to their spouses (controls), show a favorable li...
The degenerative processes that occur during aging increase the risk of disease and impaired health....
As ageing is a major risk factor for the development of non-communicable diseases, extending healths...
Understanding the complexity of aging is of utmost importance. This can now be addressed by the nove...
As centenarians well represent the model of healthy aging, there are many important implications in ...
As centenarians well represent the model of healthy aging, there are many important implications in ...
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable...
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable...
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. ...
Sphingolipids (SLs) are structural components of the lipid bilayer regulating cell functions. In bio...
Aging is a multifaceted process involving the accumulation of diverse deleterious changes in biologi...
As centenarians provide a paradigm of healthy aging, investigating the comprehensive metabolic profi...
Aging process is characterized by a progressive decline of several organic, physiological, and metab...
Organism aging is closely related to systemic metabolic changes. However, due to the multilevel and ...
Advancing age is associated with declines across numerous physiological systems, leading to an incre...
Middle-aged offspring of nonagenarians, as compared to their spouses (controls), show a favorable li...
The degenerative processes that occur during aging increase the risk of disease and impaired health....
As ageing is a major risk factor for the development of non-communicable diseases, extending healths...
Understanding the complexity of aging is of utmost importance. This can now be addressed by the nove...