Somatostatin (SRIF) is an inhibitory hormone that plays a regulatory role in several cell functions including cell proliferation. SRIF acts through five specific membrane receptors (sst1-5), expressed on SRIF-target cells. SRIF and ssts may play a significant role in the progression and neuroendocrine differentiation of human prostate cancer (PCa). However, conflicting results have been reported in the literature on ssts heterogeneity and specific cell localization in PCa. Aim of this study was to evaluate in two androgen-independent human PCa cell lines DU-145 and PC-3 cells: (a) the gene and protein expression of ssts; (b) the sub-cellular localization of the different ssts; (c) the effects of new mono- and bispecific SRIF analogs (SSAs) ...
Background: Prostate cancer (PCa) is a highly prevalent neoplasia that is strongly influenced by the...
Somatostatin (SST) inhibits cell proliferation through five SST receptors (SSTR1-5). Amongst all SST...
The aim of this study was to examine the tissue expression and localisation of the somatostatin rece...
Somatostatin (SST) and SST receptors (SS1R, SS2R, SS3R, SS4R and SS5R) appear to play a significant ...
Somatostatin (SST) and SST receptors (SS1R, SS2R, SS3R, SS4R and SS5R) appear to play a significant ...
Somatostatin (SRIF) has been demonstrated to inhibit in vitro proliferation of normal and transforme...
The evidence that prostate cancer (PCa) expresses specific receptors for hormones and neuropeptides,...
Somatostatin (SST), cortistatin (CORT), and their receptors (SSTR1-5/sst5TMD4-TMD5) comprise a multi...
Somatostatin (SST), cortistatin (CORT), and their receptors (SSTR1-5/sst5TMD4-TMD5) comprise a multi...
OBJECTIVE: The aim was to examine the expression and localization of the five somatostatin receptors...
The pharmacological effects (i.e., inhibition of endocrine secretion and cell proliferation) mediate...
The physiological actions of somatostatin-14 (SRIF: somatotrophin release inhibitory factor) recepto...
The present study was intended to gain additional information on the growth regulation of prostate b...
Prostate cancer (PCa) progression from androgen-dependent to castration-resistant disease is a proce...
The aim of the study is to examine the tissue expression and localization of the somatostatin recept...
Background: Prostate cancer (PCa) is a highly prevalent neoplasia that is strongly influenced by the...
Somatostatin (SST) inhibits cell proliferation through five SST receptors (SSTR1-5). Amongst all SST...
The aim of this study was to examine the tissue expression and localisation of the somatostatin rece...
Somatostatin (SST) and SST receptors (SS1R, SS2R, SS3R, SS4R and SS5R) appear to play a significant ...
Somatostatin (SST) and SST receptors (SS1R, SS2R, SS3R, SS4R and SS5R) appear to play a significant ...
Somatostatin (SRIF) has been demonstrated to inhibit in vitro proliferation of normal and transforme...
The evidence that prostate cancer (PCa) expresses specific receptors for hormones and neuropeptides,...
Somatostatin (SST), cortistatin (CORT), and their receptors (SSTR1-5/sst5TMD4-TMD5) comprise a multi...
Somatostatin (SST), cortistatin (CORT), and their receptors (SSTR1-5/sst5TMD4-TMD5) comprise a multi...
OBJECTIVE: The aim was to examine the expression and localization of the five somatostatin receptors...
The pharmacological effects (i.e., inhibition of endocrine secretion and cell proliferation) mediate...
The physiological actions of somatostatin-14 (SRIF: somatotrophin release inhibitory factor) recepto...
The present study was intended to gain additional information on the growth regulation of prostate b...
Prostate cancer (PCa) progression from androgen-dependent to castration-resistant disease is a proce...
The aim of the study is to examine the tissue expression and localization of the somatostatin recept...
Background: Prostate cancer (PCa) is a highly prevalent neoplasia that is strongly influenced by the...
Somatostatin (SST) inhibits cell proliferation through five SST receptors (SSTR1-5). Amongst all SST...
The aim of this study was to examine the tissue expression and localisation of the somatostatin rece...