Comparison of the Effects of Bimatoprost and a Fixed Combination of Latanoprost and Timolol on 24-Hour Blood Pressure and Ocular Perfusion Pressure

Purpose:To compare the effect of bimatoprost and the fixed combination of latanoprost and timolol (LTFC) on 24-hour systolic (SBP) and diastolic (DBP) holter blood pressure and on 24-hour ocular perfusion pressure (OPP) in glaucoma patients, in a randomized, double-masked, multicentre clinical trial. Methods:Included were patients who were controlled (IOP<21 mmHg) on the unfixed combination of latanoprost and timolol for at least 3 months prior to the baseline visit or patients on monotherapy either with latanoprost or timolol who were eligible for dual therapy not being fully controlled on monotherapy. Supine and sitting position IOPs were recorded at 8 p.m., midnight, 5 a.m., 8a.m., noon and 4 p.m. at baseline, week-6 and week-12 visits; a 24-hour blood pressure curve was obtained with holter (measurements every 15 minutes) at baseline and between week 6 and 12. Comparisons between treatments and within the 2 treatment groups with baseline were carried out with ANOVA. Rates of diastolic OPP <55, <45,