We have previously reported that a 7-d pretreatment with hexarelin, a synthetic ligand of the GH secretagogue receptor (GHS-R), largely prevented damages induced by ischemia and reperfusion in isolated rat hearts. Our aim was to ascertain whether ghrelin, an endogenous ligand of the GHS-R, is physiologically endowed with cardioprotective activity. Hypophysectomized rats were treated in vivo for 7 d with either ghrelin (320 microg/kg) or hexarelin (80 microg/kg), and their hearts were subjected in vitro to the ischemia and reperfusion procedure. Ghrelin was far less effective than hexarelin in preventing increases in left ventricular end-diastolic pressure (15% and 60% protection for ghrelin and hexarelin, respectively), coronary perfusion p...
Growth hormone (GH) may exert direct growth-promoting and metabolic actions on target tissues, but m...
Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH d...
Ghrelin and its synthetic analog hexarelin are specific ligands of growth hormone secretagogue (GHS)...
Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been reported to have...
Ghrelin, a 28 amino acid peptide endowed with a potent GH releasing activity, has been recently isol...
We administered ghrelin, a novel growth hormone-releasing hormone, to isolated perfused rat hearts, ...
Aim: To determine the cardioprotective action of ghrelin and des-octanoyl ghrelin in rats with isopr...
BACKGROUND: Ischemic heart disease is a leading cause of mortality. To study this disease, ischemia/...
We previously reported that induction of selective GH deficiency in the rat exacerbates cardiac dysf...
Background: Ischemic heart disease is a leading cause of mortality. To study this disease, ischemia/...
Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue ...
Ghrelin is a growth hormone-releasing peptide, isolated from the stomach. Researches in progress doc...
Ghrelin is a multi-functional polypeptide with cardiovascular protective effects. We aimed to explor...
The ability of hexarelin, an effective growth hormone (GH)-releasing hexapeptide, to reverse the wor...
AIM: To investigate the cardiac protective effects of ghrelin in rat with myocardial injury induced ...
Growth hormone (GH) may exert direct growth-promoting and metabolic actions on target tissues, but m...
Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH d...
Ghrelin and its synthetic analog hexarelin are specific ligands of growth hormone secretagogue (GHS)...
Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been reported to have...
Ghrelin, a 28 amino acid peptide endowed with a potent GH releasing activity, has been recently isol...
We administered ghrelin, a novel growth hormone-releasing hormone, to isolated perfused rat hearts, ...
Aim: To determine the cardioprotective action of ghrelin and des-octanoyl ghrelin in rats with isopr...
BACKGROUND: Ischemic heart disease is a leading cause of mortality. To study this disease, ischemia/...
We previously reported that induction of selective GH deficiency in the rat exacerbates cardiac dysf...
Background: Ischemic heart disease is a leading cause of mortality. To study this disease, ischemia/...
Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue ...
Ghrelin is a growth hormone-releasing peptide, isolated from the stomach. Researches in progress doc...
Ghrelin is a multi-functional polypeptide with cardiovascular protective effects. We aimed to explor...
The ability of hexarelin, an effective growth hormone (GH)-releasing hexapeptide, to reverse the wor...
AIM: To investigate the cardiac protective effects of ghrelin in rat with myocardial injury induced ...
Growth hormone (GH) may exert direct growth-promoting and metabolic actions on target tissues, but m...
Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH d...
Ghrelin and its synthetic analog hexarelin are specific ligands of growth hormone secretagogue (GHS)...