The role of mutations in protease (PR) and reverse-transcriptase (RT) of human immunodeficiency virus (HIV) in predicting virologic failure was assessed in 248 antiretroviral-naive HIV-positive patients who began a PR inhibitor-containing antiretroviral regimen. Genotypic testing was performed on plasma samples stored before the start of therapy. Twenty-seven patients (10.9%) had mutations in the RT, 5 (2%) carried primary mutations in the PR, and 131 (52.8%) showed only secondary PR mutations. Virologic failure at week 24 occurred in 62 (25.0%) of 248 patients. There was a statistically significant correlation between virologic failure and the number of PR mutations (P=.04, X2 test). Mutations at codons 10 and 36 of PR (present in 39.3% an...
Objective: To assess the prevalence of mutations in the reverse-transcriptase (RT) and protease (PR)...
In order to evaluate the usefulness of resistance testing after a viral reboundwith plasmaHIVRNA lev...
Purpose: There has been an increase in the number of individuals administered antiretroviral therap...
Abstract The role of mutations in protease (PR) and reverse-transcriptase (RT) of human immunodefici...
High-density oligonucleotide arrays were used to determine the sequence of the protease (PR) and rev...
The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline a...
Thirty-five HIV-1 infected patients showing clinical and/or immunological failure to first line anti...
BACKGROUND:Protease inhibitors (PI) are especially important in salvage therapy. Previous treatment ...
Resistance-mutation patterns in the reverse transcriptase (RT) and protease genes of HIV-1 were anal...
In order to evaluate the usefulness of resistance testing after a viral rebound with plasma HIV RNA ...
The development of antiretroviral (ARV) drugs and their use in human immunodeficiency virus type 1 (...
ABSTRACTThe aim of this study was to assess the prevalence of genetic changes in either the HIV reve...
We analyzed the first 96 patients tested for HIV resistance to antiretroviral therapy in three Brazi...
In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleo...
This study aimed at defining protease (PR) resistance mutations associated with darunavir (DRV) fail...
Objective: To assess the prevalence of mutations in the reverse-transcriptase (RT) and protease (PR)...
In order to evaluate the usefulness of resistance testing after a viral reboundwith plasmaHIVRNA lev...
Purpose: There has been an increase in the number of individuals administered antiretroviral therap...
Abstract The role of mutations in protease (PR) and reverse-transcriptase (RT) of human immunodefici...
High-density oligonucleotide arrays were used to determine the sequence of the protease (PR) and rev...
The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline a...
Thirty-five HIV-1 infected patients showing clinical and/or immunological failure to first line anti...
BACKGROUND:Protease inhibitors (PI) are especially important in salvage therapy. Previous treatment ...
Resistance-mutation patterns in the reverse transcriptase (RT) and protease genes of HIV-1 were anal...
In order to evaluate the usefulness of resistance testing after a viral rebound with plasma HIV RNA ...
The development of antiretroviral (ARV) drugs and their use in human immunodeficiency virus type 1 (...
ABSTRACTThe aim of this study was to assess the prevalence of genetic changes in either the HIV reve...
We analyzed the first 96 patients tested for HIV resistance to antiretroviral therapy in three Brazi...
In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleo...
This study aimed at defining protease (PR) resistance mutations associated with darunavir (DRV) fail...
Objective: To assess the prevalence of mutations in the reverse-transcriptase (RT) and protease (PR)...
In order to evaluate the usefulness of resistance testing after a viral reboundwith plasmaHIVRNA lev...
Purpose: There has been an increase in the number of individuals administered antiretroviral therap...