Asymmetric induction by the (S)-1-phenylethyl group in intramolecular nitrile imine cycloadditions giving enantiopure 3,3a-dihydro-pyrazolo[1,5-alpha][1,4]benzodiazepine-4(6H)-ones

Cycloaddition of benzoheteroazepine II. Reactions and conformations of cycloadducts on 1,5-benzothiazepines and 1,5-benzodiazepines with nitrile imine and nitrile oxides

Xu, Jia-Xi
Wu, Hai-Tao
Jin, Sheng

January 1999

Benzodiazepine and benzothiazepine derivatives have been well known as therapeutically important com...

Asymmetric 1,3-Dipolar Cycloadditions to 5-(R)-Menthyloxy-2(5H)-Furanone

Rispens, Minze T.
Keller, Erik
Lange, Ben de
Zijlstra, Robert W.J.
Feringa, Bernard

April 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

Asymmetric 1,3-Dipolar Cycloadditions to 5-(R)-Menthyloxy-2(5H)-Furanone

Rispens, Minze T.,
Keller, Erik,
Lange, Ben de,
Zijlstra, Robert W.J.,
Feringa, Ben L.,

January 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

The first case of asymmetric induction in intramolecular nitrile imine cycloadditions: synthesis of enantiopure 3-substituted 6-oxo-2,3,3a,5-tetrahydro-4-carbomethoxy-furo[3,4-c]pyrazoles

G. Broggini
L. Garanti
G. Molteni
G. Zecchi

January 1999

Intramolecular cycloaddition of homochiral nitrile imines 5, generated in situ from base treatment o...

The first example of a (1R,2S,5R)-(-)-menthyl chiral auxiliary in intramolecular nitrilimine cycloadditions: synthesis of enantiopure pyrazolo[1,5-a][4,1]benzoxazepines and pyrazolo[1,5-a][4,1]benzodiazepines

G. Molteni
T. Pilati

January 1999

By using (1R, 2S, 5R)-(-)-menthyl as a chiral auxiliary, we have developed a synthesis of hydrazonoy...

Stereoselective intramolecular cycloadditions of homochiral nitrilimines: synthesis of enantiopure (6S)-substituted-2,3,3a,4,5,6-hexahydro-furo[3,4-c]pyrazoles

G. Molteni
L. De Benassuti
L. Garanti

January 2004

Starting from (S)-ethyl lactate and (S)-ethyl mandelate the homochiral hydrazonoyl chlorides 4b-d ha...

Diastereoselective nitrilimine cycloaddition to the C = N bond of enantiopure 1,4-benzodiazepinones

G. Molteni
G. Broggini
T. Pilati

January 2002

Enantiopure 1,4-benzodiazepin-4-one 1 and 1,4-benzodiazepin-6-ones 2 were reacted with hydrazonoyl c...

Synthesis of enantiopure pyrrolo[3,4-c]pyrazole derivatives via intramolecular cycloaddition of homochiral nitrilimines

G. Broggini
G. Molteni
T. Pilati
G. Zecchi

January 2001

Intramolecular cycloaddition of homochiral nitrilimines 8 was exploited to obtain enantiopure pyrrol...

Stereoselective cycloadditions of nitrilimines as a source of enantiopure heterocycles

G. Molteni

January 2005

Stereoselective 1,3-dipolar cycloadditions of nitrilimines represents a useful tool in the obtainme...

Access to a Novel Class of Tetracyclic 1,4-Benzodiazepin-5-ones Starting from a-Amino Acids by Pd-Catalyzed Amination/1,3-Dipolar Cycloaddition as the Key Steps

L. Basolo
E.M. Beccalli
E. Borsini
G. Broggini
M. Khansaa
M. Rigamonti

January 2010

A convenient procedure for the preparation of the novel class of tetracyclic imidazo[2,1-c]pyrazolo[...

Asymmetric 1,3-dipolar cycloadditions to 5-(R)-menthyloxy-2(5H)-furanone

Rispens, Minze T.
Keller, Erik
de Lange, Ben
Zijlstra, Robert W.J.
Feringa, Ben L.

January 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

Diastereoselective synthesis of bis(3,5)pyrazolophanes by sequential inter- and intramolecular cycloadditions of homochiral nitrilimines

G. Broggini
G. Molteni
T. Pilati

January 2000

Starting from ethyl (S)-lactate as the chiral unit, we have developed the synthesis of the enantiopu...

Diastereoselective synthesis of enantiopure (aR)-2-methyl-4-(a-phenylethyl)-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-ones

E.M. Beccalli
G. Broggini
G. Paladino
T. Pilati
G. Pontremoli

January 2004

(\u3b1R,2R)- and (\u3b1R,2S)-2-methyl-4-(\u3b1-phenylethyl)-1,2,3,4- tetrahydro-benzo[e][1,4]diazepi...

Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamates

Wang, Yang
Wang, Qian
Zhu, Jieping

June 2016

The first catalytic asymmetric inverse electron demand 1,3-dipolar cycloaddition of azomethine imine...

Enantioselective intramolecular nitrone cycloaddition route to 3-(trifluoromethyl)-isoxazolidino[4,3-c]-chroman-4-ones and -quinolin-4-ones

A. Arnone
G. Broggini
L. Bruche
G. Molteni
G. Zecchi

January 1998

Optically active 3-(trifluoromethyl)isoxazolidino[4,3-c]-chroman-4-ones and -quinolin-4-ones are syn...

Cycloaddition of benzoheteroazepine II. Reactions and conformations of cycloadducts on 1,5-benzothiazepines and 1,5-benzodiazepines with nitrile imine and nitrile oxides

Xu, Jia-Xi
Wu, Hai-Tao
Jin, Sheng

January 1999

Benzodiazepine and benzothiazepine derivatives have been well known as therapeutically important com...

Asymmetric 1,3-Dipolar Cycloadditions to 5-(R)-Menthyloxy-2(5H)-Furanone

Rispens, Minze T.
Keller, Erik
Lange, Ben de
Zijlstra, Robert W.J.
Feringa, Bernard

April 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

Asymmetric 1,3-Dipolar Cycloadditions to 5-(R)-Menthyloxy-2(5H)-Furanone

Rispens, Minze T.,
Keller, Erik,
Lange, Ben de,
Zijlstra, Robert W.J.,
Feringa, Ben L.,

January 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

The first case of asymmetric induction in intramolecular nitrile imine cycloadditions: synthesis of enantiopure 3-substituted 6-oxo-2,3,3a,5-tetrahydro-4-carbomethoxy-furo[3,4-c]pyrazoles

G. Broggini
L. Garanti
G. Molteni
G. Zecchi

January 1999

Intramolecular cycloaddition of homochiral nitrile imines 5, generated in situ from base treatment o...

The first example of a (1R,2S,5R)-(-)-menthyl chiral auxiliary in intramolecular nitrilimine cycloadditions: synthesis of enantiopure pyrazolo[1,5-a][4,1]benzoxazepines and pyrazolo[1,5-a][4,1]benzodiazepines

G. Molteni
T. Pilati

January 1999

By using (1R, 2S, 5R)-(-)-menthyl as a chiral auxiliary, we have developed a synthesis of hydrazonoy...

Stereoselective intramolecular cycloadditions of homochiral nitrilimines: synthesis of enantiopure (6S)-substituted-2,3,3a,4,5,6-hexahydro-furo[3,4-c]pyrazoles

G. Molteni
L. De Benassuti
L. Garanti

January 2004

Starting from (S)-ethyl lactate and (S)-ethyl mandelate the homochiral hydrazonoyl chlorides 4b-d ha...

Diastereoselective nitrilimine cycloaddition to the C = N bond of enantiopure 1,4-benzodiazepinones

G. Molteni
G. Broggini
T. Pilati

January 2002

Enantiopure 1,4-benzodiazepin-4-one 1 and 1,4-benzodiazepin-6-ones 2 were reacted with hydrazonoyl c...

Synthesis of enantiopure pyrrolo[3,4-c]pyrazole derivatives via intramolecular cycloaddition of homochiral nitrilimines

G. Broggini
G. Molteni
T. Pilati
G. Zecchi

January 2001

Intramolecular cycloaddition of homochiral nitrilimines 8 was exploited to obtain enantiopure pyrrol...

Stereoselective cycloadditions of nitrilimines as a source of enantiopure heterocycles

G. Molteni

January 2005

Stereoselective 1,3-dipolar cycloadditions of nitrilimines represents a useful tool in the obtainme...

Access to a Novel Class of Tetracyclic 1,4-Benzodiazepin-5-ones Starting from a-Amino Acids by Pd-Catalyzed Amination/1,3-Dipolar Cycloaddition as the Key Steps

L. Basolo
E.M. Beccalli
E. Borsini
G. Broggini
M. Khansaa
M. Rigamonti

January 2010

A convenient procedure for the preparation of the novel class of tetracyclic imidazo[2,1-c]pyrazolo[...

Asymmetric 1,3-dipolar cycloadditions to 5-(R)-menthyloxy-2(5H)-furanone

Rispens, Minze T.
Keller, Erik
de Lange, Ben
Zijlstra, Robert W.J.
Feringa, Ben L.

January 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

Diastereoselective synthesis of bis(3,5)pyrazolophanes by sequential inter- and intramolecular cycloadditions of homochiral nitrilimines

G. Broggini
G. Molteni
T. Pilati

January 2000

Starting from ethyl (S)-lactate as the chiral unit, we have developed the synthesis of the enantiopu...

Diastereoselective synthesis of enantiopure (aR)-2-methyl-4-(a-phenylethyl)-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-ones

E.M. Beccalli
G. Broggini
G. Paladino
T. Pilati
G. Pontremoli

January 2004

(\u3b1R,2R)- and (\u3b1R,2S)-2-methyl-4-(\u3b1-phenylethyl)-1,2,3,4- tetrahydro-benzo[e][1,4]diazepi...

Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamates

Wang, Yang
Wang, Qian
Zhu, Jieping

June 2016

The first catalytic asymmetric inverse electron demand 1,3-dipolar cycloaddition of azomethine imine...

Enantioselective intramolecular nitrone cycloaddition route to 3-(trifluoromethyl)-isoxazolidino[4,3-c]-chroman-4-ones and -quinolin-4-ones

A. Arnone
G. Broggini
L. Bruche
G. Molteni
G. Zecchi

January 1998

Optically active 3-(trifluoromethyl)isoxazolidino[4,3-c]-chroman-4-ones and -quinolin-4-ones are syn...

Cycloaddition of benzoheteroazepine II. Reactions and conformations of cycloadducts on 1,5-benzothiazepines and 1,5-benzodiazepines with nitrile imine and nitrile oxides

Xu, Jia-Xi
Wu, Hai-Tao
Jin, Sheng

January 1999

Benzodiazepine and benzothiazepine derivatives have been well known as therapeutically important com...

Asymmetric 1,3-Dipolar Cycloadditions to 5-(R)-Menthyloxy-2(5H)-Furanone

Rispens, Minze T.
Keller, Erik
Lange, Ben de
Zijlstra, Robert W.J.
Feringa, Bernard

April 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

Asymmetric 1,3-Dipolar Cycloadditions to 5-(R)-Menthyloxy-2(5H)-Furanone

Rispens, Minze T.,
Keller, Erik,
Lange, Ben de,
Zijlstra, Robert W.J.,
Feringa, Ben L.,

January 1994

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar...

Asymmetric induction by the (S)-1-phenylethyl group in intramolecular nitrile imine cycloadditions giving enantiopure 3,3a-dihydro-pyrazolo[1,5-alpha][1,4]benzodiazepine-4(6H)-ones

Abstract

Extracted data

Asymmetric induction by the (S)-1-phenylethyl group in intramolecular nitrile imine cycloadditions giving enantiopure 3,3a-dihydro-pyrazolo[1,5-alpha][1,4]benzodiazepine-4(6H)-ones

Abstract

Extracted data

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