The superoxide and hydroxyl radical scavenging activities of nimesulide (CAS 51803-78-2) and its main metabolite 4-hydroxynimesulide (CAS 109032-22-6) were investigated by Election Spin Resonance (ESR) spectroscopy, with the spin trapping technique. Hydroxynimesulide is a good scavenger of both O-2 degrees(-) (IC50 = 40 mu mol/l) and HO degrees (IC50 = 54.8 mu mol/l) radicals, and its high reactivity towards HO degrees was confirmed by the rate constant for reaction with HO degrees (K = 8.9 x 10(10) mol(-1) I s(-1)) determined by competition kinetic studies with 5,5-dimethyl-1-pyrroline-N-oxide. Nimesulide, which has been shown by ESR to be inactive as a superoxide quencher, has a rate constant of reaction with HO degrees slightly greater t...
A method for correctly assessing hydroxyl radical scavenging activity of antioxidative chemicals and...
Thesis (M.Sc. (Pharmaceutical Chemistry))--North-West University, Potchefstroom Campus, 2007.Oxygen,...
In vitro investigations for the antioxidant and free radical scavenging activity of Myrtilli folium-...
The antioxidant activity of nimesulide and its main metabolites, 4'-hydroxynimesulide (M1) and 2-(4'...
AbstractObjectives Reactive oxygen species (ROS) are now recognized to play an important role in the...
OBJECTIVES: Reactive oxygen species (ROS) are now recognized to play an important role in the pathog...
The protective effect of hydroxynimesulide, the main metabolite of the nonsteroidal antiinflammatory...
238-245Antiradical activity of nimesulide, a commonly used COX-2 specific inhibitor, was estimated i...
4-nitro-2-phenoximethanesulphonanilide (nimesulide) is a nonsteroidal anti-inflammatory agent that h...
peer reviewedOBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory d...
Nimesulide has been widely used in pediatry for treatment of inflammation associated to respiratory ...
An in vitro assay based on the oxidation of phosphatidylcholine liposomes (PCL) with which we can di...
A study was undertaken for the characterization and quantitative determination of the main urinary m...
The radical scavenging activity of tenoxicam against hydroxyl (HO.), superoxide (O2(.-)), and peroxy...
Nimesulide has been widely used in pediatry for treatment of inflammation associated to respiratory ...
A method for correctly assessing hydroxyl radical scavenging activity of antioxidative chemicals and...
Thesis (M.Sc. (Pharmaceutical Chemistry))--North-West University, Potchefstroom Campus, 2007.Oxygen,...
In vitro investigations for the antioxidant and free radical scavenging activity of Myrtilli folium-...
The antioxidant activity of nimesulide and its main metabolites, 4'-hydroxynimesulide (M1) and 2-(4'...
AbstractObjectives Reactive oxygen species (ROS) are now recognized to play an important role in the...
OBJECTIVES: Reactive oxygen species (ROS) are now recognized to play an important role in the pathog...
The protective effect of hydroxynimesulide, the main metabolite of the nonsteroidal antiinflammatory...
238-245Antiradical activity of nimesulide, a commonly used COX-2 specific inhibitor, was estimated i...
4-nitro-2-phenoximethanesulphonanilide (nimesulide) is a nonsteroidal anti-inflammatory agent that h...
peer reviewedOBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory d...
Nimesulide has been widely used in pediatry for treatment of inflammation associated to respiratory ...
An in vitro assay based on the oxidation of phosphatidylcholine liposomes (PCL) with which we can di...
A study was undertaken for the characterization and quantitative determination of the main urinary m...
The radical scavenging activity of tenoxicam against hydroxyl (HO.), superoxide (O2(.-)), and peroxy...
Nimesulide has been widely used in pediatry for treatment of inflammation associated to respiratory ...
A method for correctly assessing hydroxyl radical scavenging activity of antioxidative chemicals and...
Thesis (M.Sc. (Pharmaceutical Chemistry))--North-West University, Potchefstroom Campus, 2007.Oxygen,...
In vitro investigations for the antioxidant and free radical scavenging activity of Myrtilli folium-...